CATH Superfamily 3.40.50.970

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
1	Pyruvate dehydrogenase E1 beta subunit	1456	3D	2j9fD01	-	92.9
3	Transketolase	1187	3D	1trkB02	-	95.9
2	2-oxoglutarate dehydrogenase, E1 component	1153		-	-	90.9
4	Transketolase	995	3D	1trkB01	-	91.1
5	1-deoxy-D-xylulose-5-phosphate synthase	912	3D	2o1sD02	-	95.4
7	Acetolactate synthase	831	3D	5wkcE01	-	99.3
6	Pyruvate dehydrogenase E1 component subunit beta	788	3D	6cfoD01	-	80.2
8	1-deoxy-D-xylulose-5-phosphate synthase	581	3D	2o1sD01	-	86.5
9	Pyruvate dehydrogenase E1 component	443	3D	2qtcB02	-	70.9
10	1-deoxy-D-xylulose-5-phosphate synthase	405	3D	2o1xD01	-	91.5
11	Pyruvate dehydrogenase E1 component	372	3D	2qtcB01	-	90.6
12	Pyruvate:ferredoxin Flavodoxin	363	3D	5exeD01	-	94.4
19	Pyruvate decarboxylase isozyme	346	3D	2w93D01	-	90.2
13	Pyruvate dehydrogenase E1 component subunit alpha	328		-	-	94.5
14	2-oxoglutarate dehydrogenase E1 component	324	3D	2jgdB02	-	70.9
15	2-oxoisovalerate dehydrogenase subunit alpha	319	3D	2j9fC00	-	91.3
18	2-oxoglutarate dehydrogenase E1 component	293	3D	6i2qA02	-	57.6
16	Acetolactate synthase	291		-	-	86.8
17	pyruvate decarboxylase 1	286		-	-	75.8
24	Pyruvate decarboxylase isozyme	277	3D	2w93D03	-	95.4
20	Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	276	3D	6cfoC00	-	79.4
29	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	243	3D	5z2uH01	-	52.6
21	Pyruvate decarboxylase 1	213		-	-	73.2
23	Pyruvate dehydrogenase E1 component subunit alpha	213	3D	3dvaG00	-	56.2
35	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	211	3D	5z2uH03	-	10.4
22	2-oxoglutarate ferredoxin oxidoreductase alpha subunit	203	3D	4wbxC01	-	96.2
25	Ubiquinone-dependent pyruvate dehydrogenase	160	3D	3eyaL01	-	47.4
28	Transketolase isoform 1	148	3D	4kxyB02	-	75.1
26	Glyoxylate carboligase	146	3D	2panF03	-	41.8
27	2-hydroxyacyl-CoA lyase 1	140		-	-	82.8
31	Pyruvate dehydrogenase [ubiquinone]	134	3D	3eyaL03	-	53.5
30	1-deoxy-D-xylulose-5-phosphate synthase	130		-	-	70.7
33	Transketolase isoform 1	128	3D	4kxyB01	-	89.4
32	2-oxoisovalerate dehydrogenase subunit alpha	120		-	-	77.7
34	Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial	111		-	-	85.8
40	Oxalyl-CoA decarboxylase	99	3D	2q29B01	-	64.3
36	2-oxoglutarate dehydrogenase E1 component	96		-	-	87.6
41	Pyruvate:ferredoxin Flavodoxin	96	3D	2uzaB06	-	83.9
53	Acetolactate synthase, mitochondrial	95	3D	5wkcE03	-	78.4
42	Oxalyl-CoA decarboxylase	90	3D	2q29B03	-	81.8
38	2-hydroxyacyl-CoA lyase 1 isoform X1	88		-	-	83.0
37	2-oxoacid:ferredoxin oxidoreductase subunit beta	88		-	-	41.2
39	Indolepyruvate oxidoreductase subunit IorA	84		-	-	96.5
45	Transketolase	70	3D	3m7iA02	-	92.1
43	IlvB acetolactate synthase like	68		-	-	50.4
44	Putative acetolactate synthase IlvG	66		-	-	85.2
47	Probable pyruvate-flavodoxin oxidoreductase	62		-	-	47.8
46	2-hydroxyacyl-CoA lyase 1	62		-	-	46.1
48	IlvB bacterial acetolactate synthase	58		-	-	54.3
49	2-oxoglutarate ferredoxin oxidoreductase subunit beta	52		-	-	77.5
51	Sulfite reductase beta subunit	45		-	-	85.5
50	2-hydroxyacyl-CoA lyase	45		-	-	81.9
52	Sulfite reductase [NADPH] flavoprotein component	42		-	-	90.0
54	Putative 2-hydroxyphytanoyl-CoA lyase	42		-	-	84.6
55	2-oxoisovalerate dehydrogenase subunit alpha	27		-	-	81.9
66	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	25	3D	5esdD01	-	24.1
58	Putative pyruvate decarboxylase	24		-	-	59.3
56	3D- 3,5/4	24		-	-	23.1
57	2-oxoisovalerate dehydrogenase subunit alpha	24		-	-	73.6
68	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	23	3D	5esdD03	-	14.2
130	N 2 2-carboxyethyl	22	3D	2ihvD03	-	7.9
61	2-oxoglutarate dehydrogenase E1 component	21		-	-	39.2
60	1-deoxy-D-xylulose-5-phosphate synthase	21		-	-	11.8
139	Pyruvate oxidase	21	3D	2ezuB01	-	0.0
59	2-oxoisovalerate dehydrogenase E1 component	21		-	-	21.0
63	2-oxoglutarate dehydrogenase, mitochondrial	20		-	-	17.7
62	Acetolactate synthase, catabolic	20		-	-	37.7
65	Oxoglutarate dehydrogenase Succinyl-transferring	19		-	-	10.0
64	1-deoxy-D-xylulose 5-phosphate synthase	19		-	-	3.5
81	Transketolase	17	3D	3m7iA01	-	91.9
67	2-hydroxyacyl-CoA lyase 1	16		-	-	48.4
69	1-deoxy-D-xylulose 5-phosphate synthase	15		-	-	0.8
70	2-oxoglutarate dehydrogenase E1 component	15		-	-	22.0
71	2-hydroxyphytanoyl-CoA lyase, putative	15		-	-	81.1
140	Pyruvate oxidase	15	3D	1y9dD03	-	0.0
76	Transketolase	14		-	-	82.7
75	Oxoglutarate dehydrogenase Succinyl-transferring	14		-	-	14.8
74	2-oxoglutarate dehydrogenase E1 component	14		-	-	14.0
73	2-oxoisovalerate dehydrogenase subunit alpha	14		-	-	33.9
72	3D- 3,5/4	14		-	-	10.1
82	Oxoglutarate dehydrogenase	13		-	-	41.3
79	Indolepyruvate ferredoxin oxidoreductase alpha subunit	13		-	-	43.1
77	Pyruvate dehydrogenase E1 component subunit beta	13		-	-	32.4
80	Indolepyruvate oxidoreductase subunit IorA	13		-	-	83.5
78	Sulfite reductase NADPH	13		-	-	15.1
84	Probable 2-ketoarginine decarboxylase AruI	12		-	-	26.8
83	Sulfite reductase NADPH	12		-	-	15.5
91	Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase	11		-	-	68.7
88	Putative acetolactate synthase IlvG	11		-	-	13.1
90	Sulfoacetaldehyde acetyltransferase	11		-	-	27.8
89	Putative indole-3-pyruvate decarboxylase	11		-	-	2.0
87	Thi3p	11		-	-	41.1
86	Sulfite reductase NADPH	11		-	-	5.4
85	Sulfite reductase [NADPH] subunit beta	11		-	-	77.3
96	Pyruvate dehydrogenase E1 alpha 1 subunit	10		-	-	33.3
93	1-deoxy-D-xylulose-5-phosphate synthase	10		-	-	38.0
94	2-oxoisovalerate dehydrogenase E1 component	10		-	-	8.9
95	Sulfopyruvate decarboxylase subunit beta	10		-	-	84.2
92	2-oxoglutarate decarboxylase/hydro-lyase/magnesium ion-binding protein	10		-	-	12.4
99	Probable acetohydroxyacid synthase ilvX	9		-	-	20.9
97	Met5 protein	9		-	-	1.2
98	Sulfite reductase alpha subunit	9		-	-	0.6
101	Putative phosphonopyruvate decarboxylase	9		-	-	79.9
100	Putative phosphonopyruvate decarboxylase	9		-	-	85.0
102	Protein PHYLLO, chloroplastic	8		-	-	22.2
104	1-deoxy-D-xylulose-5-phosphate synthase	8		-	-	9.9
107	Sulfoacetaldehyde acetyltransferase Xsc	8		-	-	79.2
103	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	8		-	-	7.7
105	2-oxoglutarate dehydrogenase E1 component, putative	8		-	-	31.7
106	Pyruvate:ferredoxin Flavodoxin	8		-	-	2.6
108	2-oxoisovalerate dehydrogenase subunit alpha	8		-	-	79.8
114	Indolepyruvate ferredoxin oxidoreductase alpha subunit	7		-	-	45.5
109	Indolepyruvate oxidoreductase subunit IorA	7		-	-	71.4
113	Oxalate oxidoreductase subunit beta	7		-	-	11.8
112	Dehydrogenase E1 component	7		-	-	0.0
111	Uncharacterized protein	7		-	-	65.5
115	Probable acetohydroxyacid synthase ilvX	7		-	-	9.1
110	Pyruvate-flavodoxin oxidoreductase	7		-	-	2.3
117	Transketolase	6		-	-	11.1
120	Pyruvate dehydrogenase Ferredoxin/flavodoxin-dependent	6		-	-	6.6
119	2-oxoglutarate dehydrogenase, putative	6		-	-	40.2
116	Indolepyruvate oxidoreductase subunit IorA	6		-	-	80.7
118	Indolepyruvate oxidoreductase subunit IorA	6		-	-	12.5
121	Sulfite reductase beta subunit	5		-	-	10.2
125	2-oxoacid:ferredoxin oxidoreductase, beta subunit	5		-	-	2.1
126	Phosphonopyruvate decarboxylase-like protein	5		-	-	10.6
128	Putative 2-oxoglutarate dehydrogenase subunit	5		-	-	29.8
129	Transketolase	5		-	-	54.6
122	Related to MET10-sulfite reductase flavin-binding subunit	5		-	-	16.6
124	1-deoxy-D-xylulose-5-phosphate synthase	5		-	-	0.0
127	Phosphonopyruvate decarboxylase-like protein	5		-	-	7.0
123	Putative acetolactate synthase large subunit	5		-	-	0.0
134	Pyruvate dehydrogenase E1 component subunit alpha	4		-	-	10.3
133	1-deoxy-D-xylulose-5-phosphate synthase	4		-	-	11.2
132	2-oxoisovalerate dehydrogenase, E1 component, alpha and beta subunit	4		-	-	0.0
131	2-oxoisovalerate dehydrogenase, E1 component, alpha and beta subunit	4		-	-	0.3
144	1-deoxy-D-xylulose-5-phosphate synthase	3		-	-	0.0
137	Sulfite reductase [NADPH] flavoprotein component, putative	3		-	-	3.5
147	Pyruvate dehydrogenase E1 component subunit beta	3		-	-	12.9
143	1-deoxy-D-xylulose-5-phosphate synthase	3		-	-	0.0
149	Pyruvate-flavodoxin oxidoreductase	3		-	-	0.0
142	Phenylpyruvate decarboxylase	3		-	-	8.6
146	2-hydroxyacyl-CoA lyase	3		-	-	19.7
136	Putative inositol polyphosphate phosphatase Synaptogenin-like	3		-	-	70.7
148	Pyruvate dehydrogenase E1 component subunit beta	3		-	-	9.9
138	NADH-dependent phenylglyoxylate dehydrogenase subunit beta	3		-	-	6.1
141	Acetolactate synthase-1/2/3 large subunit	3		-	-	15.6
151	2-oxoisovalerate dehydrogenase subunit alpha	3		-	-	66.2
150	Pyruvate dehydrogenase E1 component beta subunit	3		-	-	1.7
135	Uncharacterized protein	3		-	-	66.8
145	Uncharacterized protein	3		-	-	18.0
154	Predicted protein	2		-	-	33.8
163	Transketolase putative	2		-	-	41.2
173	Uncharacterized protein	2		-	-	24.7
177	Pyruvate dehydrogenase E1 component alpha subunit, putative	2		-	-	0.0
167	Uncharacterized protein	2		-	-	2.3
164	Thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	2		-	-	0.0
174	Predicted protein	2		-	-	29.3
153	Indolepyruvate oxidoreductase subunit IorA	2		-	-	0.0
157	Predicted protein	2		-	-	0.0
162	Benzaldehyde lyase, putative	2		-	-	10.0
172	2-oxoisovalerate dehydrogenase subunit alpha	2		-	-	27.6
169	Pyruvate dehydrogenase E1 component beta subunit	2		-	-	0.0
179	Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial	2		-	-	12.8
180	Oxoglutarate dehydrogenase Succinyl-transferring	2		-	-	7.2
181	2-oxoglutarate dehydrogenase, mitochondrial	2		-	-	1.0
152	Indolepyruvate oxidoreductase subunit IorA	2		-	-	4.9
159	Oxoglutarate dehydrogenase	2		-	-	5.6
183	Transketolase-1 chloroplastic	2		-	-	29.9
156	Uncharacterized protein	2		-	-	40.7
168	Transketolase chloroplast putative	2		-	-	0.0
178	Indolepyruvate oxidoreductase subunit IorA	2		-	-	8.6
166	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	2		-	-	0.0
176	Pyruvate dehydrogenase E1 component alpha subunit, putative	2		-	-	0.0
158	Uncharacterized protein	2		-	-	9.5
160	Sulfite reductase NADPH	2		-	-	0.0
170	Alpha-ketoacid dehydrogenase subunit beta	2		-	-	0.0
165	2-oxoglutarate:ferredoxin oxidoreductase, thiamin diphosphate-binding subunit	2		-	-	0.0
175	Uncharacterized protein	2		-	-	24.5
182	2-oxoglutarate dehydrogenase, E1 protein	2		-	-	0.0
155	2-oxoglutarate dehydrogenase, putative	2		-	-	24.6
161	Probable 2-hydroxyacyl-CoA lyase 1	2		-	-	16.6
171	2-oxoisovalerate dehydrogenase subunit alpha	2		-	-	37.0
229	Transketolase, putative	1		-	-	0.0
188	Pyruvate:ferredoxin oxidoreductase F	1		-	-	0.0
222	2-hydroxyacyl-CoA lyase 1	1		-	-	0.0
200	Acetolactate synthase, catabolic, putative	1		-	-	0.0
218	Uncharacterized protein	1		-	-	0.0
197	Pyruvate decarboxylase	1		-	-	0.0
193	Uncharacterized protein	1		-	-	0.0
205	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	1		-	-	0.0
194	Thiamine diphosphate dependent-3-acetyloctanal synthase PigD	1		-	-	0.0
186	Predicted protein	1		-	-	0.0
201	Probable 2-ketoarginine decarboxylase AruI	1		-	-	0.0
216	Pyruvate decarboxylase 2	1		-	-	0.0
227	Predicted protein	1		-	-	0.0
208	Putative 2-dehydropantoate 2-reductase	1		-	-	0.0
215	Uncharacterized protein	1		-	-	0.0
223	Uncharacterized protein	1		-	-	0.0
192	Predicted protein	1		-	-	0.0
210	Uncharacterized protein	1		-	-	0.0
185	Uncharacterized protein	1		-	-	0.0
199	2-hydroxyphytanoyl-CoA lyase, putative	1		-	-	0.0
235	Oxoglutarate dehydrogenase	1		-	-	0.0
230	Uncharacterized protein	1		-	-	0.0
231	Uncharacterized protein	1		-	-	0.0
206	Predicted protein	1		-	-	0.0
211	2-oxoisovalerate dehydrogenase subunit alpha	1		-	-	0.0
224	Pyruvate dehydrogenase E1 alpha 1 subunit	1		-	-	0.0
209	Uncharacterized protein	1		-	-	0.0
187	Uncharacterized protein	1		-	-	0.0
233	Putative 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial-like Protein	1		-	-	0.0
217	Uncharacterized protein	1		-	-	0.0
198	Uncharacterized protein	1		-	-	0.0
213	Uncharacterized protein	1		-	-	0.0
225	2-oxoisovalerate dehydrogenase subunit alpha	1		-	-	0.0
202	Uncharacterized protein	1		-	-	0.0
220	2-oxoisovalerate dehydrogenase subunit alpha	1		-	-	0.0
221	Uncharacterized protein	1		-	-	0.0
214	Protein CBG00293	1		-	-	0.0
196	Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial	1		-	-	0.0
184	Uncharacterized protein	1		-	-	0.0
234	2-oxoglutarate dehydrogenase E1 component	1		-	-	0.0
212	Pyruvate dehydrogenase E1 alpha 1 subunit b	1		-	-	0.0
190	Uncharacterized protein	1		-	-	0.0
207	Pyruvate ferredoxin oxidoreductase B	1		-	-	0.0
228	Gll1094 protein	1		-	-	0.0
189	Uncharacterized protein	1		-	-	0.0
203	Uncharacterized protein	1		-	-	0.0
195	Pyruvate decarboxylase 2	1		-	-	0.0
232	Uncharacterized protein	1		-	-	0.0
219	Uncharacterized protein, isoform F	1		-	-	0.0
226	Gll1094 protein	1		-	-	0.0
204	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	1		-	-	0.0
191	Sulfite reductase [NADPH] subunit beta	1		-	-	0.0

Network disruptions

CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

Functional Families

Browse Functional Families