CATH Domain 2panF03

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.970	Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

Domain Context

CATH Clusters

Superfamily	3.40.50.970
Functional Family	Glyoxylate carboligase

Enzyme Information

4.1.1.47

Tartronate-semialdehyde synthase.

based on mapping to UniProt P0AEP7

2 glyoxylate = tartronate semialdehyde + CO(2).

UniProtKB Entries (1)

GCL_ECOLI

Escherichia coli K-12

Glyoxylate carboligase

PDB Structure

PDB	2PAN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes. Kaplun, A., Binshtein, E., Vyazmensky, M., Steinmetz, A., Barak, Z., Chipman, D.M., Tittmann, K., Shaanan, B. Nat.Chem.Biol.