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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
voltage-gated potassium channel subunit beta-2 isoform X2
483
3D
 1zsxA00 - 76.5
3
Aldo-keto reductase family 1 member C3
425
3D
 6f78B00 - 91.4
9
Aldo-keto reductase family 1 member B1
337
3D
 6f8oA00 - 90.3
2
2,5-diketo-D-gluconic acid reductase A
283
3D
 1mzrB00 - 97.8
4
Oxidoreductase, aldo/keto reductase
250
3D
 1pz1B00 - 98.5
7
NAD
P
234
3D
 5zcmA00 - 96.8
5
NADP
H
221
3D
 1lqaB00 - 84.1
6
Aldo-keto reductase family 1 member A1
211
3D
 4gacB00 - 95.6
8
Aldo/keto reductase family oxidoreductase
196
3D
 1ur3M00 - 91.3
15
Oxidoreductase, aldo/keto reductase family
108
3D
 1vp5B00 - 97.0
10
NADPH-dependent aldo-keto reductase, chloroplastic
106
3D
 3h7uA00 - 81.8
11
Aldo/keto reductase
98 - - 94.1
13
NADPH-dependent codeinone reductase 1-1
97
3D
 2vdgA00 - 91.2
17
Aflatoxin B1 aldehyde reductase member 2
93
3D
 2bp1D00 - 59.7
12
Glutamate--cysteine ligase regulatory subunit
92 - - 79.8
14
NAD
P
84 - - 91.1
16
2,5-diketo-D-gluconic acid reductase B
76 - - 29.3
20
L-glyceraldehyde 3-phosphate reductase
68
3D
 4aubG00 - 17.5
18
Glycerol dehydrogenase Gcy1
57 - - 85.0
19
NADP-dependent D-sorbitol-6-phosphate dehydrogenase
49 - - 67.7
21
Hypothetical oxidoreductase YdbC
49 - - 10.8
22
Oxidoreductase, aldo/keto reductase family
45 - - 6.4
23
aldose reductase
45 - - 90.6
24
Aryl-alcohol dehydrogenase
38 - - 71.2
26
Gamma-cysteine synthetase regulatory subunit, putative
37 - - 72.5
25
NADP
+
37 - - 56.7
31
D-arabinose dehydrogenase heavy chain
37
3D
 4ijrC00 - 84.0
27
Aldo/keto reductase
37 - - 43.0
29
Aldo-keto reductase
36
3D
 1qwkA00 - 92.5
28
Oxidoreductase, aldo/keto reductase family
36 - - 6.0
30
Aldo-keto reductase family 1 member E2
33 - - 63.0
32
Hyperkinetic, isoform I
32 - - 17.3
33
Aldo/keto reductase
29 - - 19.0
34
Chromosome 7, whole genome shotgun sequence
26 - - 90.1
68
Aldo-keto reductase family 1 member B10
26
3D
 5y7nA00 - 54.7
35
Aldehyde reductase, putative
24 - - 17.5
36
NADP-dependent oxidoreductase domain-containing protein
20 - - 81.6
37
L-galactose dehydrogenase
L-GalDH
20 - - 71.6
38
Aldo/keto reductase
19 - - 33.0
63
Aldo/keto reductase
19
3D
 4exbF00 - 2.1
39
Putative oxidoreductase
18 - - 81.2
40
Putative aldo-keto reductase
17 - - 3.1
42
Probable voltage-gated potassium channel subunit beta
16 - - 34.1
43
Pyridoxal reductase, chloroplastic
16 - - 49.1
41
D-arabinose 1-dehydrogenase
16 - - 73.9
44
Aldose reductase
16 - - 82.6
45
Aldo-keto reductase
AKR
14 - - 84.9
47
Putative aldo/keto reductase
13 - - 8.0
46
Aldo-keto reductase family 1, member B10
aldose reductase
13 - - 75.1
49
Oxidoreductase, aldo/keto reductase family protein
12 - - 88.1
48
Probable aldo-keto reductase 4
12 - - 55.3
51
Putative pyridoxal reductase
AKR8
11 - - 73.6
53
Aldo-keto oxidoreductase
11 - - 86.6
52
2,5-diketo-D-gluconic acid reductase A
11 - - 84.1
50
Aldo-keto reductase family 1 member C2
11 - - 49.8
54
L-fucose dehydrogenase
10 - - 19.5
55
Putative oxidoreductase, chloroplastic
10 - - 22.2
56
Aldo-keto reductase-like protein
10 - - 82.2
58
Aldose reductase, putative
9 - - 70.0
57
Uncharacterized protein
9 - - 59.2
60
Putative oxidoreductase
8 - - 0.0
59
Conserved protein
8 - - 1.7
62
Oxidoreductase, aldo/keto reductase family
7 - - 0.8
61
Aldo/keto reductase, putative
7 - - 83.4
64
Aldo-keto reductase 1a
7 - - 80.5
65
Aryl-alcohol dehydrogenase
6 - - 11.3
67
Related to GCY1-galactose-induced protein of aldo/keto reductase family / uncharacterized protein
6 - - 19.8
66
Aldo/keto reductase
6 - - 2.3
76
Galactose dehydrogenase
5 - - 10.2
70
Aldo/keto reductase
5 - - 75.4
75
GD18440
5 - - 15.8
72
Aldose reductase, putative
5 - - 0.4
80
Aldo-keto reductase family 4 member C8
5
3D
 3h7rA00 - 12.5
69
Protein CBG12061
5 - - 42.2
74
Oxidoreductase, aldo/keto reductase family
5 - - 2.9
71
Aldose reductase
5 - - 9.3
73
Prostaglandin f synthase. putative
5 - - 0.0
82
Oxidoreductase, aldo/keto reductase family
4 - - 9.1
79
glutamate--cysteine ligase regulatory subunit-like
4 - - 62.3
77
Alcohol dehydrogenase, putative
4 - - 11.4
81
Uncharacterized oxidoreductase MSMEG_2408
4 - - 6.0
78
Aldo-keto reductase family 1 member D1
4 - - 72.3
83
Aryl-alcohol dehydrogenase
4 - - 3.8
84
Glycerol dehydrogenase
GCY1
4 - - 71.6
87
Aldo-keto reductase family 1 member D1
3 - - 48.2
85
Uncharacterized protein
3 - - 18.2
90
Aldehyde reductase protein
3 - - 7.3
92
Oxidoreductase
3 - - 3.8
89
Aldo-keto reductase family 1, member B1
aldose reductase
3 - - 10.6
86
Putative sterigmatocystin biosynthesis dehydrogenase stcV
3 - - 27.1
94
AGAP012038-PA
3 - - 13.3
91
NADPH-dependent aldo-keto reductase, chloroplastic isoform A
3 - - 2.3
93
Aldose reductase
3 - - 6.7
88
Uncharacterized protein
3 - - 76.2
123
Aflatoxin B1 aldehyde reductase member 2
2 - - 11.1
96
Aldo-keto reductase family 4 member C9
2 - - 31.2
111
Oxidoreductase
2 - - 0.0
131
NADP
+ Eurofung
2 - - 0.0
117
Uncharacterized protein
2 - - 1.0
118
AKR1E2 isoform 12
2 - - 2.4
122
L-galactose dehydrogenase isoform A
2 - - 0.0
106
Uncharacterized protein
2 - - 3.3
100
Hypothetical protein LOC594893
2 - - 7.5
99
Oxidoreductase, aldo/keto reductase family protein
2 - - 7.6
124
Aldo-keto reductase family 1, member C20
2 - - 7.9
126
Aldo-keto reductase family 1, member C20
2 - - 1.3
102
Predicted protein
2 - - 1.8
95
Uncharacterized protein
2 - - 23.5
104
Probable oxidoreductase
Aldo-keto reductase family protein
2 - - 0.0
120
Glutamate--cysteine ligase regulatory subunit
2 - - 0.7
97
Uncharacterized protein
2 - - 35.1
115
Uncharacterized protein
2 - - 1.7
103
Putative oxidoreductase
2 - - 8.7
119
Uncharacterized protein
2 - - 0.0
121
Uncharacterized protein
2 - - 0.0
113
Aldo/keto reductase
2 - - 7.5
109
Uncharacterized protein
2 - - 0.4
133
LOC100127714 protein
2 - - 39.0
105
Predicted protein
2 - - 0.0
128
NADP
+ Eurofung
2 - - 0.0
98
Os10g0113375 protein
2 - - 41.0
127
Glycerol dehydrogenase
GCY1
2 - - 0.0
112
Probable L-fucose dehydrogenase
2 - - 9.3
114
Aldo/keto reductase
2 - - 0.0
132
Predicted protein
2 - - 35.0
130
NADP
+ Eurofung
2 - - 0.0
116
Aldehyde reductase, putative
2 - - 2.5
110
Uncharacterized protein
2 - - 1.0
107
Putative oxidoreductase-possibly Aldo/keto reductase
2 - - 4.5
108
Chromosome 21, whole genome shotgun sequence
2 - - 7.4
125
Galactose dehydrogenase
2 - - 45.9
101
Probable oxidoreductase
2 - - 6.3
129
NADP
+ Eurofung
2 - - 0.0
217
Aldo-keto-reductase-like protein
1 - - 0.0
166
Glutamate--cysteine ligase regulatory subunit-like Protein
1 - - 0.0
185
Uncharacterized protein
1 - - 0.0
153
Uncharacterized protein
1 - - 0.0
218
Aldo-keto-reductase-like protein
1 - - 0.0
160
AGAP012851-PA
1 - - 0.0
145
Uncharacterized protein
1 - - 0.0
200
Aldo-keto reductase, putative
1 - - 0.0
172
Uncharacterized protein
1 - - 0.0
189
Predicted protein
1 - - 0.0
149
Uncharacterized protein
1 - - 0.0
174
Oxidoreductase, aldo/keto reductase family protein
1 - - 0.0
206
Os05g0456200 protein
1 - - 0.0
137
Predicted protein
1 - - 0.0
173
Uncharacterized protein
1 - - 0.0
138
Uncharacterized protein
1 - - 0.0
211
Uncharacterized protein
1 - - 0.0
190
Uncharacterized protein
1 - - 0.0
152
Uncharacterized protein
1 - - 0.0
196
Uncharacterized protein
1 - - 0.0
154
Uncharacterized protein
1 - - 0.0
156
Predicted protein
1 - - 0.0
215
Sorting nexin 2B
1 - - 0.0
188
Uncharacterized protein
1 - - 0.0
187
Uncharacterized protein
1 - - 0.0
163
Oxidoreductase, aldo/keto reductase family protein
1 - - 0.0
194
Uncharacterized protein
1 - - 0.0
147
Predicted protein
1 - - 0.0
192
Uncharacterized protein
1 - - 0.0
150
Uncharacterized oxidoreductase C28F2.05
1 - - 0.0
148
Uncharacterized protein
1 - - 0.0
219
Uncharacterized protein
1 - - 0.0
203
Galactose dehydrogenase
1 - - 0.0
204
Uncharacterized protein
1 - - 0.0
220
Uncharacterized protein
1 - - 0.0
135
Uncharacterized protein
1 - - 0.0
176
Oxidoreductase, aldo/keto reductase family protein
1 - - 0.0
141
Uncharacterized oxidoreductase C215.11c
1 - - 0.0
181
Uncharacterized protein
1 - - 0.0
202
Uncharacterized protein
1 - - 0.0
170
Oxidoreductase, aldo/keto reductase family protein
1 - - 0.0
162
MIP04347p
1 - - 0.0
139
Uncharacterized protein
1 - - 0.0
164
Predicted protein
1 - - 0.0
193
Alcohol dehydrogenase [NADP
+
1 - - 0.0
151
Uncharacterized protein
1 - - 0.0
199
Aldo-keto reductase family 1, member C19
1 - - 0.0
177
Uncharacterized protein
1 - - 0.0
178
Uncharacterized protein
1 - - 0.0
214
Uncharacterized protein
1 - - 0.0
195
Uncharacterized protein
1 - - 0.0
212
Uncharacterized protein
1 - - 0.0
209
Uncharacterized protein
1 - - 0.0
180
Uncharacterized protein
1 - - 0.0
171
Uncharacterized protein
1 - - 0.0
146
Uncharacterized protein
1 - - 0.0
186
Uncharacterized protein
1 - - 0.0
158
Aldo-keto reductase, putative
1 - - 0.0
213
Uncharacterized protein
1 - - 0.0
140
Predicted protein
1 - - 0.0
165
Oxidoreductase, aldo/keto reductase family protein
1 - - 0.0
157
Uncharacterized protein
1 - - 0.0
134
Uncharacterized protein
1 - - 0.0
205
Uncharacterized protein
1 - - 0.0
169
Uncharacterized protein
1 - - 0.0
161
Potassium voltage-gated channel, shaker-related subfamily, beta member 2 b
1 - - 0.0
175
Oxidoreductase, aldo/keto reductase family protein
1 - - 0.0
136
dTDP-4-keto-L-6-deoxy-hexose 2,3-reductase-putative a NADP-dependent oxidoreductase
1 - - 0.0
198
Uncharacterized protein
1 - - 0.0
142
Uncharacterized protein
1 - - 0.0
184
Aldo-keto reductase, putative
1 - - 0.0
197
Uncharacterized protein
1 - - 0.0
144
Uncharacterized protein
1 - - 0.0
182
Uncharacterized protein
1 - - 0.0
179
Predicted protein
1 - - 0.0
201
Uncharacterized protein
1 - - 0.0
143
Uncharacterized protein
1 - - 0.0
210
Bifunctional protein STORR
1 - - 0.0
168
Uncharacterized protein
1 - - 0.0
167
Putative glutamate--cysteine ligase regulatory subunit
1 - - 0.0
155
Predicted protein
1 - - 0.0
183
Uncharacterized protein
1 - - 0.0
216
Aldo-keto-reductase-like protein
1 - - 0.0
207
Uncharacterized protein
1 - - 0.0
208
Uncharacterized protein
1 - - 0.0
191
Uncharacterized protein
1 - - 0.0
159
Uncharacterized protein
1 - - 0.0
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