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CATH Superfamily 2.20.70.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
1717
3D
 2zajA01 - 89.5
2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1
1086 - - 78.8
3
amyloid beta A4 precursor protein-binding family B member 2
1023
3D
 2e45A01 - 92.7
4
dystrophin isoform X1
799
3D
 1eg4A01 - 74.7
5
E3 ubiquitin-protein ligase
602
3D
 5dwsC01 - 94.1
6
E3 ubiquitin-protein ligase NEDD4-like protein
568
3D
 5ahtA01 - 75.6
7
E3 ubiquitin-protein ligase HECW2 isoform X1
559 - - 76.7
8
E3 ubiquitin-protein ligase NEDD4-like protein
417 - - 77.8
9
E3 ubiquitin-protein ligase
377 - - 68.1
10
Transcription elongation regulator 1
CA150
353
3D
 2dk7A00 - 79.2
11
E3 ubiquitin-protein ligase
350 - - 68.5
12
transcriptional coactivator YAP1 isoform X2
323
3D
 4rexA00 - 95.0
13
E3 ubiquitin-protein ligase HECW2 isoform X1
293 - - 68.4
14
E3 ubiquitin-protein ligase SMURF1
281 - - 64.0
15
Transcription elongation regulator 1
CA150
274 - - 74.5
17
E3 ubiquitin-protein ligase
257
3D
 2kxqA02 - 93.1
16
Transcription elongation regulator 1
CA150
256
3D
 2ysiA01 - 59.5
18
DGCR8 microprocessor complex subunit
245
3D
 3le4A00 - 87.7
19
Putative transcriptional coactivator YAP1
227
3D
 2l4jA00 - 88.8
20
WW domain-containing adapter protein with coiled-coil isoform X1
223 - - 65.6
21
E3 ubiquitin-protein ligase NEDD4
218 - - 81.0
22
Rho GTPase activating protein 39
215 - - 81.0
23
E3 ubiquitin-protein ligase
213 - - 73.2
24
Rho GTPase activating protein 12
207 - - 57.0
26
E3 ubiquitin-protein ligase
200 - - 45.9
25
E3 ubiquitin-protein ligase NEDD4-like protein
200 - - 34.1
27
pleckstrin homology domain-containing family A member 5 isoform X1
192 - - 66.3
28
WW domain-containing protein
184 - - 65.0
29
pre-mRNA-processing factor 40 homolog A isoform X1
177 - - 58.3
30
Salvador family WW domain-containing protein 1
174 - - 56.6
31
pre-mRNA-processing factor 40 homolog A isoform X1
173 - - 58.8
32
WW domain containing oxidoreductase
169 - - 70.5
34
syntaxin-binding protein 4 isoform X1
165
3D
 2ysgA01 - 81.1
33
Growth arrest specific 7
165 - - 51.1
36
Phosphorylated CTD-interacting factor 1
163
3D
 2jx8A00 - 94.9
35
Salvador homolog 1
Drosophila
163
3D
 2ysbA01 - 74.4
37
E3 ubiquitin-protein ligase nedd-4
156
3D
 2ez5W01 - 78.2
46
Peptidyl-prolyl cis-trans isomerase
155
3D
 5uy9A01 - 80.2
38
E3 ubiquitin-protein ligase
152 - - 50.5
39
E3 ubiquitin-protein ligase
147 - - 58.2
40
WW domain containing oxidoreductase
142 - - 59.5
41
WW and C2 domain containing 1
131 - - 76.7
43
Pleckstrin homology domain-containing, family A member 5
128 - - 12.5
42
Histone-lysine N-methyltransferase
128 - - 33.7
44
E3 ubiquitin-protein ligase SMURF2
127 - - 78.6
45
E3 ubiquitin-protein ligase NEDD4-like
123 - - 64.8
47
E3 ubiquitin-protein ligase
119 - - 60.0
48
HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1
118 - - 44.9
49
Transcription elongation regulator 1-like
116 - - 97.7
50
pre-mRNA-processing factor 40 homolog B isoform X1
116 - - 88.8
51
probable phosphoinositide phosphatase SAC9
100 - - 77.9
53
E3 ubiquitin-protein ligase
92 - - 72.8
52
pre-mRNA-processing factor 40 homolog B isoform X1
92 - - 65.4
55
E3 ubiquitin-protein ligase NEDD4-like isoform X1
90 - - 70.6
54
E3 ubiquitin-protein ligase SMURF1
90 - - 31.5
56
Formin binding protein 4
82 - - 72.6
58
Formin binding protein 4
80 - - 46.1
57
FERM and PDZ domain-containing protein 4
80 - - 58.3
59
pleckstrin homology domain-containing family A member 7
76 - - 39.5
60
E3 ubiquitin-protein ligase
70 - - 44.6
61
Rho GTPase activating protein 27
66 - - 71.3
63
E3 ubiquitin-protein ligase NEDD4
62
3D
 5cq2A02 - 87.2
62
IQ motif containing GTPase activating protein 1
61 - - 56.3
64
rho GTPase-activating protein 9 isoform X2
58 - - 74.0
65
Rho GTPase activating protein 27
58 - - 66.4
66
Peptidyl-prolyl cis-trans isomerase
53
3D
 2jv4A00 - 91.9
67
Pre-mRNA-processing protein 40C
49 - - 75.8
68
E3 ubiquitin-protein ligase
49 - - 60.4
69
Neural precursor cell expressed, developmentally down-regulated 4-like
46 - - 34.8
70
Pre-mRNA-processing protein 40C
44 - - 78.4
71
FERM domain
Protein4.1-ezrin-radixin-moesin
42 - - 64.8
73
Rho GTPase activating protein 9
40 - - 68.3
72
Rho GTPase activating protein 12b
40 - - 61.1
74
E3 ubiquitin-protein ligase
36 - - 47.6
75
Pre-mRNA-processing protein 40A isoform A
34 - - 79.4
76
Polyglutamine-binding protein 1
33 - - 2.2
77
E3 ubiquitin-protein ligase
31 - - 63.4
79
FCA gamma protein
30 - - 63.2
78
Formin binding protein
FNB3
30 - - 76.2
80
E3 ubiquitin-protein ligase
29 - - 39.9
83
pre-mRNA-processing factor 40 homolog A isoform X3
28 - - 62.5
82
Phosphorylated CTD-interacting factor
28 - - 71.7
84
E3 ubiquitin-protein ligase
28 - - 67.7
81
PDZ domain-containing protein
28 - - 60.4
85
Peptidyl-prolyl cis-trans isomerase
27 - - 86.9
86
NEDD4-like E3 ubiquitin-protein ligase WWP1
26 - - 39.8
88
WW domain-binding protein 4
26
3D
 2jxwA00 - 17.6
87
PArtner of DroSHa
DRSH-1 interactor
26 - - 76.4
90
Formin binding protein
FNB3
24 - - 78.2
89
Blast:WW domain-containing adapter protein with coiled-coil
24 - - 19.1
91
Flowering time control protein FCA isoform A
23 - - 65.6
92
WW domain-binding protein 4
22 - - 72.4
93
NEDD4-like E3 ubiquitin-protein ligase WWP1
22 - - 47.7
94
transcriptional coactivator YAP1 isoform X1
21 - - 16.4
96
E3 ubiquitin-protein ligase NEDD4 isoform X4
20 - - 33.1
95
Pre-mRNA-processing factor 40
20 - - 77.1
97
Dystrophin-1
18 - - 9.5
98
RNA-binding protein, putative
18 - - 3.4
100
Pre-mRNA-processing protein 40A isoform A
18 - - 41.3
99
E3 ubiquitin-protein ligase NEDD4
18 - - 42.7
103
nudix hydrolase 23, chloroplastic-like
17 - - 25.9
102
Pre-mRNA-processing factor 40 homolog B
17 - - 84.4
101
Pre-mRNA-processing factor 40
17 - - 79.4
104
Uncharacterized protein, isoform B
16 - - 30.6
106
CUGBP Elav-like family member 2
16 - - 11.7
105
Pre-mRNA-processing factor 40, putative
16 - - 56.2
107
Chromosome 19, whole genome shotgun sequence
16 - - 83.7
109
Putative pre-mRNA-processing factor 40
15 - - 8.5
110
CUGBP Elav-like family member 1
15 - - 12.9
111
E3 ubiquitin-protein ligase
15 - - 40.1
108
growth arrest-specific protein 7 isoform X2
15 - - 22.2
112
Yorkie, isoform G
14 - - 59.1
113
Clustered-asparagine-rich protein
14 - - 0.0
114
Transcription elongation regulator
13 - - 58.9
115
WW domain-containing oxidoreductase isoform X4
12 - - 15.4
116
Transcription elongation regulator 1
12 - - 26.5
117
Pre-mRNA-processing protein 40B
12 - - 69.7
118
Transcription elongation regulator 1
12 - - 55.6
119
WW_domain_containing_protein_-_putative
11 - - 54.4
120
mRNA cap guanine-N7 methyltransferase
11 - - 13.6
121
Transcription elongation regulator 1
11 - - 74.3
123
Uncharacterized protein
10 - - 23.0
122
Peptidyl-prolyl cis-trans isomerase
10 - - 51.9
126
E3 ubiquitin-protein ligase
9 - - 15.9
125
E3 ubiquitin-protein ligase Smurf1
9 - - 45.6
124
DEAD box RNA helicase family protein
9 - - 38.2
131
WW domain-containing oxidoreductase
8 - - 13.4
129
Transcription factor TFIIE alpha subunit
8 - - 66.7
128
WW domain-containing protein tag-325
8 - - 28.0
132
U1 snRNP protein
8 - - 43.8
134
Uncharacterized protein, isoform C
8 - - 65.1
133
TransCription Elongation Regulator homolog
8 - - 68.2
127
Pre-mRNA-processing protein 40A
8 - - 74.0
135
U1 snRNP protein
8
3D
 1o6wA02 - 0.0
130
Pre-mRNA-splicing factor dre4
8 - - 79.6
137
Histone-lysine N-methyltransferase
7 - - 70.5
140
GL18629
7 - - 20.0
138
WW domain containing protein
7 - - 0.0
139
E3 ubiquitin-protein ligase Smurf1
7 - - 13.5
136
Pre-mRNA-processing protein 40A
7 - - 11.6
142
TransCription Elongation Regulator homolog
6 - - 19.1
143
Histone-lysine N-methyltransferase, H3 lysine-36 specific
6 - - 75.2
141
Uncharacterized protein
6 - - 8.6
149
Rho GTPase-activating protein 27
5 - - 74.1
144
Pre-mRNA-processing factor 40 homolog A
5 - - 22.6
151
E3 ubiquitin-protein ligase
5 - - 4.6
145
E3 ubiquitin-protein ligase
5 - - 41.4
146
E3 ubiquitin-protein ligase
5 - - 70.6
152
Pre-mRNA-processing factor 40 homolog A
5 - - 83.0
154
Uncharacterized protein
5 - - 92.4
147
Chromosome 19, whole genome shotgun sequence
5 - - 74.4
153
Pre-mRNA-processing factor 40 homolog A-like Protein
5 - - 72.4
150
E3 ubiquitin-protein ligase hecw-1
5 - - 16.5
155
WW domain-containing protein A
5 - - 49.6
148
AFR317Cp
5 - - 78.7
167
E3 ubiquitin-protein ligase
4 - - 18.3
157
E3 ubiquitin-protein ligase
4 - - 64.5
170
Rho GTPase-activating protein 27
4 - - 67.4
161
E3 ubiquitin-protein ligase hecw-1
4 - - 23.1
168
Uncharacterized protein
4 - - 39.2
158
Predicted protein
4 - - 50.7
162
Uncharacterized protein
4 - - 12.9
169
Pre-mRNA processing protein, putative
4 - - 48.1
159
Predicted protein
4 - - 77.1
163
Histone-lysine N-methyltransferase
4 - - 3.3
164
WW_domain_containing_protein_-_putative
4 - - 5.3
160
Pre-mRNA-splicing factor cwc2
4 - - 50.9
165
Yes-associated protein homolog 1
4 - - 26.2
156
Uncharacterized protein
4 - - 28.6
166
WW domain containing protein, putative
4 - - 0.0
172
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
3 - - 35.9
185
Peptidyl-prolyl cis-trans isomerase
3 - - 74.7
179
YALI0C19404p
3 - - 0.0
180
Pre-mRNA-processing factor 40
3 - - 5.8
173
S-adenosyl-L-methionine-dependent methyltransferase superfamily protein
3 - - 47.1
174
Predicted protein
3 - - 57.6
186
E3 ubiquitin-protein ligase
3 - - 69.3
175
Uncharacterized protein
3 - - 0.0
182
E3 ubiquitin-protein ligase
3 - - 4.4
183
E3 ubiquitin-protein ligase
3 - - 0.0
176
Histone-lysine N-methyltransferase
3 - - 12.5
184
E3 ubiquitin-protein ligase
3 - - 50.0
181
Reticulocyte-binding protein 2-like protein a
3 - - 46.0
177
PQBP1
Polyglutamine tract-binding neurodegeneration protein
3 - - 18.1
171
Uncharacterized protein
3 - - 33.8
187
Uncharacterized protein
3 - - 47.9
178
Histone-lysine N-methyltransferase
3 - - 0.0
227
Uncharacterized protein
2 - - 0.0
208
Uncharacterized protein
2 - - 0.0
235
WW domain containing protein
2 - - 44.9
230
Uncharacterized protein
2 - - 38.1
211
Uncharacterized protein
2 - - 8.3
218
Rho GTPase-activating protein 27,-like
2 - - 0.0
197
Histone-lysine N-methyltransferase, H3 lysine-36 specific
2 - - 0.0
201
Uncharacterized protein
2 - - 2.7
236
Uncharacterized protein
2 - - 45.3
207
YALI0D02827p
2 - - 0.0
228
Pre-mRNA-processing protein 40A
2 - - 45.3
189
MIP25048p
2 - - 2.6
232
Uncharacterized protein
2 - - 52.3
191
Predicted protein
2 - - 47.9
233
Uncharacterized protein
2 - - 55.8
217
Histone-lysine N-methyltransferase
2 - - 0.0
198
transcriptional coactivator YAP1 isoform X2
2 - - 0.0
221
Putative mitochondrial protein
2 - - 6.3
234
Uncharacterized protein
2 - - 42.0
215
WW domain containing protein, putative
2 - - 0.0
223
E3 ubiquitin-protein ligase
2 - - 30.4
192
Uncharacterized protein
2 - - 48.7
210
Rho GTPase activating protein 27
2 - - 11.1
199
Uncharacterized protein
2 - - 4.4
231
Transcription elongation regulator, putative
2 - - 40.3
206
Uncharacterized protein
2 - - 0.0
224
E3 ubiquitin-protein ligase
2 - - 2.8
229
Predicted protein
2 - - 0.0
188
Peptidyl-prolyl cis-trans isomerase
2 - - 26.3
222
E3 ubiquitin-protein ligase
2 - - 48.5
200
Pre-mRNA-splicing factor URN1
2 - - 0.0
205
Uncharacterized protein
2 - - 5.4
193
Uncharacterized protein
2 - - 46.9
194
Uncharacterized protein
2 - - 50.1
216
Uncharacterized protein
2 - - 2.1
212
Membrane-associated guanylate kinase, WW and PDZ domain-containing 3b
2 - - 0.0
190
Uncharacterized protein
2 - - 40.2
195
Pasha/DGCR8
2 - - 0.0
203
Uncharacterized protein
2 - - 8.1
219
Zygote-specific protein 3
2 - - 0.0
226
WW domain-containing protein A
2 - - 42.2
204
Uncharacterized protein
2 - - 0.0
237
Uncharacterized protein
2 - - 54.2
209
WW domain containing protein, putative
2 - - 0.0
213
Histone-lysine N-methyltransferase
2 - - 0.0
225
E3 ubiquitin-protein ligase
2 - - 0.0
202
mRNA cap guanine-N7 methyltransferase
2 - - 12.8
220
WW domain-containing protein WWM1
2 - - 47.0
214
YALI0D02827p
2 - - 0.0
196
Rho GTPase-activating protein 27,-like
2 - - 0.0
250
Uncharacterized protein
1 - - 0.0
255
Uncharacterized protein
1 - - 0.0
271
Histone-lysine N-methyltransferase
1 - - 0.0
260
Predicted protein
1 - - 0.0
290
Uncharacterized protein
1 - - 0.0
265
Uncharacterized protein
1 - - 0.0
241
Peptidyl-prolyl cis-trans isomerase
1 - - 0.0
248
Uncharacterized protein
1 - - 0.0
266
Uncharacterized protein
1 - - 0.0
287
Uncharacterized protein
1 - - 0.0
256
Predicted protein
1 - - 0.0
278
WW domain protein
1 - - 0.0
281
Predicted protein
1 - - 0.0
239
Peptidyl-prolyl cis-trans isomerase
1 - - 0.0
252
Uncharacterized protein
1 - - 0.0
259
Uncharacterized protein
1 - - 0.0
292
Uncharacterized protein
1 - - 0.0
262
Uncharacterized protein
1 - - 0.0
269
Rho GTPase activating protein 27
1 - - 0.0
264
Uncharacterized protein
1 - - 0.0
247
Histone-lysine N-methyltransferase, H3 lysine-36 specific
1 - - 0.0
253
Membrane associated guanylate kinase, WW and PDZ domain containing 3
1 - - 0.0
254
Uncharacterized protein
1 - - 0.0
288
Uncharacterized protein
1 - - 0.0
263
Predicted protein
1 - - 0.0
277
Uncharacterized protein
1 - - 0.0
240
Peptidyl-prolyl cis-trans isomerase
1 - - 0.0
291
Uncharacterized protein
1 - - 0.0
261
Predicted protein
1 - - 0.0
245
Chromosome 9, whole genome shotgun sequence
1 - - 0.0
270
Uncharacterized protein
1 - - 0.0
275
Uncharacterized protein
1 - - 0.0
289
Pre-mRNA-processing protein 40A
1 - - 0.0
282
Uncharacterized protein
1 - - 0.0
251
Uncharacterized protein
1 - - 0.0
238
Peptidyl-prolyl cis-trans isomerase
1 - - 0.0
276
Predicted protein
1 - - 0.0
258
Uncharacterized protein
1 - - 0.0
284
Predicted protein
1 - - 0.0
283
Uncharacterized protein
1 - - 0.0
246
Uncharacterized protein
1 - - 0.0
268
Rho GTPase-activating protein 27
1 - - 0.0
249
Uncharacterized protein
1 - - 0.0
242
Peptidyl-prolyl cis-trans isomerase
1 - - 0.0
272
Uncharacterized protein
1 - - 0.0
285
E3 ubiquitin-protein ligase
1 - - 0.0
279
Uncharacterized protein
1 - - 0.0
280
Uncharacterized protein
1 - - 0.0
274
RNA binding protein
1 - - 0.0
286
Neural cell expressed, developmentally down-regulated 4-like
1 - - 0.0
243
Uncharacterized protein
1 - - 0.0
257
Uncharacterized protein
1 - - 0.0
244
ADR159Cp
1 - - 0.0
273
Rho GTPase activating protein 27, like
1 - - 0.0
267
E3 ubiquitin-protein ligase HECW2-like Protein
1 - - 0.0
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