×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 1.20.120.1070

Translation initiation factor eIF-2B, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Translation initiation factor eIF-2B, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Translation initiation factor eIF-2B, N-terminal domain

Translation initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. The eukaryotic translation initiation factor eIF-2B is a complex which comprises five different subunits, alpha, beta, gamma, delta and epsilon, and catalyses the exchange of eIF-2-bound GDP for GTP PMID:19631657. Structural domains comprising this superfamily share the structure of the N-terminal alpha helical domain of the eukaryotic translation initiation factor (eIF-2B) and are found in initiation factor 2B alpha, beta and delta subunits from eukaryotes; related proteins from archaebacteria and IF-2 from prokaryotes in addition to a subfamily of proteins in eukaryotes, archaea, or eubacteria (INTERPRO:IPR000649).

GO Diversity

Unique GO annotations
26 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1322 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 8
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 16
Function
Unique EC:
Unique GO: 26
Taxonomy
Unique Species: 1322
CATH-Gene3D is a Global Biodata Core Resource Learn more...