CATH Domain 6cx1C00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.20

Domain Context

CATH Clusters

Superfamily	2.60.120.20
Functional Family	Genome polyprotein

Enzyme Information

2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt Q155Z9 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.6.4.13	RNA helicase. based on mapping to UniProt Q155Z9 ATP + H(2)O = ADP + phosphate. -!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
3.4.22.28	Picornain 3C. based on mapping to UniProt Q155Z9 Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. -!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
3.4.19.12	Ubiquitinyl hydrolase 1. based on mapping to UniProt Q155Z9 Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). -!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (2)

Q155Z9	POLG_SVV1 Seneca Valley virus USA/SSV-001 Genome polyprotein
Q9H6X2	ANTR1_HUMAN Homo sapiens Anthrax toxin receptor 1

PDB Structure

PDB	6CX1
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus. Jayawardena, N., Burga, L.N., Easingwood, R.A., Takizawa, Y., Wolf, M., Bostina, M. Proc. Natl. Acad. Sci. U.S.A.