CATH Domain 5wyxA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.80	Alpha-Beta Horseshoe
	3.80.10	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
	3.80.10.10	Ribonuclease Inhibitor

Domain Context

CATH Clusters

Superfamily	Ribonuclease Inhibitor
Functional Family	Toll-like receptor 7

Enzyme Information

UniProtKB Entries (1)

TLR8_HUMAN

Homo sapiens

Toll-like receptor 8

PDB Structure

PDB	5WYX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small-molecule inhibition of TLR8 through stabilization of its resting state Zhang, S., Hu, Z., Tanji, H., Jiang, S., Das, N., Li, J., Sakaniwa, K., Jin, J., Bian, Y., Ohto, U., Shimizu, T., Yin, H. Nat. Chem. Biol.