CATH Domain 5tf5B03

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Enzyme Information

2.6.1.7	Kynurenine--oxoglutarate transaminase. based on mapping to UniProt Q8N5Z0 L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. -!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
2.6.1.39	2-aminoadipate transaminase. based on mapping to UniProt Q8N5Z0 L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.

UniProtKB Entries (1)

AADAT_HUMAN

Homo sapiens

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

PDB Structure

PDB	5TF5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure and mechanistic analysis of a novel human kynurenine aminotransferase-2 reversible inhibitor Nematollahi, A., Sun, G., Jayawickrama, G., Hanrahan, J.R., Church, W.B. Med.Chem.Res.