CATH Domain 5og0A01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	Serine--pyruvate aminotransferase

Enzyme Information

2.6.1.51	Serine--pyruvate transaminase. based on mapping to UniProt P21549 L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. -!- The liver enzyme may be identical with EC 2.6.1.44.
2.6.1.44	Alanine--glyoxylate transaminase. based on mapping to UniProt P21549 L-alanine + glyoxylate = pyruvate + glycine. -!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. -!- A second component also catalyzes the reaction of EC 2.6.1.51.

UniProtKB Entries (1)

SPYA_HUMAN

Homo sapiens

Serine--pyruvate aminotransferase

PDB Structure

PDB	5OG0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis. Giardina, G., Paiardini, A., Montioli, R., Cellini, B., Voltattorni, C.B., Cutruzzola, F. Sci Rep