CATH Domain 4q6rB02

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	Sphingosine-1-phosphate lyase 1

Enzyme Information

4.1.2.27

Sphinganine-1-phosphate aldolase.

based on mapping to UniProt O95470

Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.

UniProtKB Entries (1)

SGPL1_HUMAN

Homo sapiens

Sphingosine-1-phosphate lyase 1

PDB Structure

PDB	4Q6R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis. Weiler, S., Braendlin, N., Beerli, C., Bergsdorf, C., Schubart, A., Srinivas, H., Oberhauser, B., Billich, A. J.Med.Chem.