CATH Domain 4emoB00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Domain Context

CATH Clusters

Superfamily	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family	sharpin isoform X1

Enzyme Information

UniProtKB Entries (1)

SHRPN_HUMAN

Homo sapiens

Sharpin

PDB Structure

PDB	4EMO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold. Stieglitz, B., Haire, L.F., Dikic, I., Rittinger, K. J.Biol.Chem.