CATH Domain 3oseA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.310	TATA-Binding Protein
	3.30.310.80	Kinase associated domain 1, KA1

Domain Context

CATH Clusters

Superfamily	Kinase associated domain 1, KA1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.26	[Tau protein] kinase. based on mapping to UniProt Q9P0L2 ATP + [tau protein] = ADP + [tau protein] phosphate. -!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.
2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt Q9P0L2 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

MARK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase MARK1

PDB Structure

PDB	3OSE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids. Moravcevic, K., Mendrola, J.M., Schmitz, K.R., Wang, Y.H., Slochower, D., Janmey, P.A., Lemmon, M.A. Cell(Cambridge,Mass.)