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1 keywords

CATH Domain 2jqiA00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.200 Tumour Suppressor Smad4
Homologous Superfamily 2.60.200.20  

Domain Context

CATH Clusters

Superfamily 2.60.200.20
Functional Family Serine/threonine-protein kinase RAD53

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P22216
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P22216
RAD53_YEAST
Saccharomyces cerevisiae S288C
Serine/threonine-protein kinase RAD53

PDB Structure

PDB 2JQI
External Links
Method SOLUTION NMR
Organism
Primary Citation
Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.
Lee, H., Yuan, C., Hammet, A., Mahajan, A., Chen, E.S., Wu, M.R., Su, M.I., Heierhorst, J., Tsai, M.D.
Mol.Cell
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