CATH Domain 2gdgC00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.429	Macrophage Migration Inhibitory Factor
	3.30.429.10	Macrophage Migration Inhibitory Factor

Domain Context

CATH Clusters

Superfamily	Macrophage Migration Inhibitory Factor
Functional Family	Macrophage migration inhibitory factor

Enzyme Information

5.3.2.1	Phenylpyruvate tautomerase. based on mapping to UniProt P34884 Keto-phenylpyruvate = enol-phenylpyruvate. -!- Also acts on other arylpyruvates.
5.3.3.12	L-dopachrome isomerase. based on mapping to UniProt P34884 L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. -!- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate). -!- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).

UniProtKB Entries (1)

MIF_MOUSE

Mus musculus

Macrophage migration inhibitory factor

PDB Structure

PDB	2GDG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate. Golubkov, P.A., Johnson Jr., W.H., Czerwinski, R.M., Person, M.D., Wang, S.C., Whitman, C.P., Hackert, M.L. Bioorg.Chem.