×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Domain Context

CATH Clusters

Superfamily Urease, subunit C, domain 1
Functional Family Cytosine deaminase

Enzyme Information

3.5.4.1
Cytosine deaminase.
based on mapping to UniProt P25524
Cytosine + H(2)O = uracil + NH(3).
-!- Also acts on 5-methylcytosine.
3.5.4.-
In cyclic amidines.
based on mapping to UniProt P25524

UniProtKB Entries (1)

P25524
CODA_ECOLI
Escherichia coli K-12
Cytosine deaminase

PDB Structure

PDB 1RAK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Mahan, S.D., Ireton, G.C., Knoeber, C., Stoddard, B.L., Black, M.E.
Protein Eng.Des.Sel.
CATH-Gene3D is a Global Biodata Core Resource Learn more...