CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.60 | Lipoxygenase-1 |
|
2.60.60.20 | PLAT/LH2 domain |
Domain Context
CATH Clusters
| Superfamily | PLAT/LH2 domain |
| Functional Family | Triacylglycerol lipase |
Enzyme Information
| 3.1.1.3 |
Triacylglycerol lipase.
based on mapping to UniProt P16233
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
-!- The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.
|
| 3.1.1.26 |
Galactolipase.
based on mapping to UniProt P81139
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D- galactosyl-sn-glycerol + 2 carboxylates.
-!- Also acts on 2,3-di-O-acyl-1-O-(6-O-alpha-D-galactosyl-beta-D- galactosyl)-D-glycerol, and phosphatidylcholine and other phospholipids.
|
| 3.1.1.3 |
Triacylglycerol lipase.
based on mapping to UniProt P81139
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
-!- The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.
|
UniProtKB Entries (2)
| P81139 |
LIPR2_CAVPO
Cavia porcellus
Pancreatic lipase-related protein 2
|
| P16233 |
LIPP_HUMAN
Homo sapiens
Pancreatic triacylglycerol lipase
|
PDB Structure
| PDB | 1GPL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig.
Structure
|
