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CATH Superfamily 3.90.70.10

Cysteine proteinases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 39: Cysteine proteinase 2, putative

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histolysain. [EC: 3.4.22.35]
Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-|-Xaa in small molecule substrates including Z-Arg-Arg-|-NHMec.
  • From the protozoan, Entamoeba histolytica.
  • Belongs to peptidase family C1.
 25 M2RGE9 M2RGE9 M2RGE9 M2RGE9 M2RGE9 M3S7G8 M3S7G8 M3S7G8 M3S7G8 M3S7G8
(15 more...)
Cathepsin H. [EC: 3.4.22.16]
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.
  • Present in lysosomes of mammalian cells.
  • Because of the combination of endopeptidase and aminopeptidase activity it can be considered as 'endoaminopeptidase'.
  • Belongs to peptidase family C1.
 14 A0A384KV08 A0A384KV08 A0A384KV08 B9DG56 B9DG56 B9DG56 M0VNM8 M0VNM8 P05167 P05167
(4 more...)
Cathepsin L. [EC: 3.4.22.15]
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
  • A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64.
  • Belongs to peptidase family C1.
 1 O45734