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CATH Superfamily 3.90.70.10

Cysteine proteinases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Calpain-1 catalytic subunit

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Calpain-2. [EC: 3.4.22.53]
Broad endopeptidase specificity.
  • Cytosolic in animal cells.
  • The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52.
  • Belongs to peptidase family C2.
  • Formerly EC 3.4.22.17 and EC 3.4.24.5.
 24 A0A2K6CM66 A0A2K6CM66 A0A2K6CM66 A0A2K6CM66 A0A2K6LKA2 A0A2K6LKA2 A0A2K6LKA2 A0A2K6LKA2 A6NHC0 H9EQA5
(14 more...)
Calpain-1. [EC: 3.4.22.52]
Broad endopeptidase specificity.
  • Cytosolic in animal cells.
  • The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53.
  • Belongs to peptidase family C2.
  • Formerly EC 3.4.22.17 and EC 3.4.24.5.
 19 A0A2K6E1E7 A0A2K6E1E7 A0A2K6E1E7 H9G0C4 H9G0C4 H9G0C4 O35350 O35350 P00789 P07384
(9 more...)
Calpain-3. [EC: 3.4.22.54]
Broad endopeptidase activity.
  • Activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site.
  • Substrates include the protein itself and connectin/titin.
  • Belongs to peptidase family C2.
 16 A0A2K6CWT0 A0A2K6CWT0 A0A2K6CWT0 F7G8S2 F7G8S2 F7G8S2 P16259 P20807 P43368 P51186
(6 more...)