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CATH Superfamily 3.40.720.10

Alkaline Phosphatase, subunit A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alkaline Phosphatase, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
613
3D
 4qaxA01 - 94.0
2
Phosphopentomutase
397 - - 63.8
3
Extracellular sulfatase
385 - - 71.1
4
Arylsulfatase E
306
3D
 1p49A01 - 87.8
5
Phosphopentomutase
305
3D
 4lrfC01 - 79.4
6
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
259
3D
 5liaA03 - 76.7
8
Alkaline phosphatase
221
3D
 3mk2A00 - 94.6
7
Arylsulfatase family, member J
211
3D
 1fsuA01 - 70.0
10
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
182
3D
 4gtzB01 - 83.2
9
Phosphoglycerol transferase I
181 - - 22.4
11
Non-specific phospholipase C1
161 - - 81.9
40
Alkaline phosphatase
136
3D
 5c66B00 - 38.7
13
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
135
3D
 3nvlB01 - 79.6
12
N-acetylglucosamine-6-sulfatase
132 - - 77.0
15
GPI ethanolamine phosphate transferase 1
124 - - 88.3
14
Hydrolase, inner membrane
124 - - 18.4
16
Phosphoethanolamine transferase CptA
123 - - 43.2
17
Predicted protein
123 - - 95.6
18
Putative GPI ethanolamine phosphate transferase 2
114 - - 74.5
21
Galactosamine
N-acetyl
113
3D
 4fdjB01 - 76.1
19
Phosphoethanolamine transferase ybiP
112 - - 29.1
20
Phosphatidylinositol glycan anchor biosynthesis class N
111 - - 42.0
23
Arylsulfatase A
104
3D
 1n2lA01 - 87.2
22
Phosphoethanolamine transferase eptA
101
3D
 5fgnA02 - 86.0
26
N-sulphoglucosamine sulphohydrolase
97
3D
 4mivH01 - 80.6
24
Sulfatase YdeN
89 - - 19.0
25
GPI ethanolamine phosphate transferase 3 isoform X1
88 - - 67.8
27
iduronate 2-sulfatase
82 - - 90.2
29
ectonucleotide pyrophosphatase/phosphodiesterase family member 6
79
3D
 5eghB01 - 74.1
28
Non-specific phospholipase C1
79 - - 81.9
31
arylsulfatase G isoform X1
65 - - 73.6
30
Phosphoethanolamine transferase eptB
65 - - 17.7
35
Ectonucleotide pyrophosphatase/phosphodiesterase 4
Putative
63
3D
 4lr2A01 - 70.7
32
Choline sulfatase
63 - - 88.2
33
Alkaline-phosphatase-like family protein
62 - - 83.8
34
Membrane-associated phospholipase C
60 - - 83.5
36
Membrane-associated phospholipase C
54 - - 82.1
37
Nucleotide pyrophosphatase family protein
54 - - 86.2
44
Arylsulfatase
47
3D
 5aj9B01 - 75.4
38
Arylsulfatase AtsA
46 - - 63.4
39
arylsulfatase K
45 - - 77.2
41
GPI ethanolamine phosphate transferase 3
41 - - 83.7
42
Alkaline-phosphatase-like family protein
39 - - 30.1
43
Acid phosphatase PHOa
39 - - 71.4
45
GPI ethanolamine phosphate transferase 2
32 - - 75.5
48
ectonucleotide pyrophosphatase/phosphodiesterase family member 7
32
3D
 5udyA01 - 86.2
47
Arylsulfatase
31 - - 89.4
46
DUF229 domain-containing protein
31 - - 10.4
49
Alkaline phosphatase
29 - - 44.8
50
Extracellular sulfatase SULF-1
29 - - 79.4
51
Arylsulfatase
28 - - 77.8
52
Phosphatidylglycerol specific phospholipase, putative
28 - - 80.5
53
GPI ethanolamine phosphate transferase 2 isoform X1
24 - - 35.9
54
non-specific phospholipase C6
24 - - 49.7
62
Probable sulfatase
21
3D
 4uplC01 - 76.8
55
Sulfatase
21 - - 1.2
57
Arylsulfatase
20 - - 4.1
56
Phosphatidylinositol glycan, class O
20 - - 73.0
60
Phosphatidylglycerol specific phospholipase C, putative
19 - - 53.2
58
Phosphoethanolamine N-methyltransferase, putative
AFU_orthologue AFUA_6G04290
19 - - 55.7
61
Sulfatase atsG
19 - - 94.0
59
Arylsulfatase
19 - - 12.4
63
Alkaline phosphatase
18 - - 70.9
64
Probable acid phosphatase Pho610
17 - - 82.3
65
Arylsulfatase A
16 - - 89.4
67
Predicted protein
15 - - 72.3
66
Non-specific phospholipase C6
15 - - 41.9
70
Arylsulfatase A
14 - - 88.4
69
Phosphate starvation-inducible protein PsiE
14 - - 7.6
68
Predicted protein
14 - - 37.5
72
GPI ethanolamine phosphate transferase 3,putative
13 - - 3.7
71
Metalloenzyme domain protein
13 - - 5.8
73
Cofactor-independent phosphoglycerate mutase
13 - - 20.8
76
Phosphoglycerol transferase MdoB-like protein, alkaline phosphatase superfamily
12 - - 78.4
75
GPI ethanolamine phosphate transferase 3,putative
12 - - 10.4
74
GPI ethanolamine phosphate transferase 1
12 - - 75.1
79
Non-specific phospholipase C5
11 - - 35.9
77
Ectonucleotide pyrophosphatase/phosphodiesterase 3
11 - - 7.5
80
N-acetylgalactosamine 6-sulfatase
GALNS
11 - - 85.1
78
GPI ethanolamine phosphate transferase 2 isoform X4
11 - - 63.2
85
Non-specific phospholipase C3
10 - - 12.8
82
Protein CBG10792
10 - - 84.4
92
Alkaline phosphatase PafA
10
3D
 5tooA01 - 49.7
81
Protein CBG02074
10 - - 40.0
83
Hydrolase of alkaline phosphatase superfamily
10 - - 0.4
84
Uncharacterized protein
10 - - 12.6
87
Arylsulfatase B
9 - - 82.3
86
CRE-SUL-1 protein
9 - - 14.8
113
Phosphonoacetate hydrolase
9
3D
 1ei6D01 - 12.2
88
Phosphatidylinositol glycan anchor biosynthesis, class N
9 - - 80.9
90
DUF4976 domain-containing protein
8 - - 8.8
89
Sulfatase
8 - - 0.0
91
Phosphatidylinositol glycan anchor biosynthesis, class N
8 - - 75.1
93
arylsulfatase B isoform X1
8 - - 20.6
100
YhbX/YhjW/YijP/YjdB family protein
7 - - 11.6
99
Arylsulphatase A
7 - - 73.1
96
AGAP004721-PA
7 - - 34.7
97
Predicted protein
7 - - 75.4
141
Alkaline phosphatase PhoK
7
3D
 5xwkA01 - 11.6
102
Cofactor-independent phosphoglycerate mutase
7 - - 16.0
95
GPI ethanolamine phosphate transferase 3
7 - - 42.8
94
Iduronate 2-sulfatase
7 - - 30.8
98
Arylsulfatase
7 - - 81.2
101
Secreted sulfatase ydeN
7 - - 70.4
106
Arylsulfatase
6 - - 46.1
111
Predicted protein
6 - - 83.4
103
2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like
6 - - 38.0
104
2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like
6 - - 34.4
112
Uncharacterized protein
6 - - 82.6
109
Arylsulfatase A
6 - - 83.0
105
Phosphatidylinositol glycan anchor biosynthesis, class G
6 - - 68.7
110
Phosphatidylinositol glycan, class O
6 - - 47.4
107
Phosphatidylglycerol specific phospholipase, putative
6 - - 27.3
108
Arylsulfatase A [precursor]
6 - - 78.4
117
Predicted protein
5 - - 85.2
118
Lipid A phosphoethanolamine transferase
5 - - 9.0
122
Sulfatase 2a
5 - - 56.8
123
Predicted protein
5 - - 72.9
115
GPI ethanolamine phosphate transferase 3
5 - - 71.9
119
GM20960
5 - - 13.5
120
GG16284
5 - - 11.2
114
Putative integral membrane protein
5 - - 19.5
121
Uncharacterized protein
5 - - 47.3
116
GPI ethanolamine phosphate transferase 3 isoform X1
5 - - 43.7
137
Phosphatidylinositol-glycan biosynthesis class O protein, putative
4 - - 16.5
138
Acid phosphatase
4 - - 0.0
124
Ectonucleotide pyrophosphatase/phosphodiesterase 1
4 - - 35.5
131
Uncharacterized protein
4 - - 27.7
135
Protein CBG05971
4 - - 10.4
139
Galactosamine
N-acetyl
4 - - 10.1
126
Arylsulfatase family member H
4 - - 43.5
262
Phosphonate monoester hydrolase, putative
4
3D
 4upkC01 - 0.0
128
Iduronate-sulfatase or arylsulfatase A
4 - - 6.8
127
N-acetylgalactosamine-6-sulfatase
GALNS
4 - - 7.2
140
Predicted protein
4 - - 58.9
134
Iduronate-2-sulfatase
4 - - 14.2
132
AT28040p
4 - - 36.6
133
GPI ethanolamine phosphate transferase 2-like Protein
4 - - 39.7
143
N-acetylgalactosamine-6-sulfate sulfatase
4 - - 48.2
125
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
4 - - 59.8
129
Protein CBG23355
4 - - 27.0
130
GPI ethanolamine phosphate transferase 1
4 - - 15.2
136
Phosphoglycerol transferase
4 - - 1.2
142
Predicted protein
4 - - 67.5
152
Lipid A phosphoethanolamine transferase
3 - - 1.4
154
N-sulfoglucosamine sulfohydrolase
3 - - 5.5
166
Type I phosphodiesterase/nucleotide pyrophosphatase
3 - - 4.7
153
Heparan N-sulfatase
3 - - 7.5
145
Uncharacterized protein
3 - - 35.8
160
Arylsulfatase A
3 - - 11.9
149
PhosphatidylInositol Glycan anchor biosynthesis class G
3 - - 23.0
170
Predicted protein
3 - - 37.2
162
Predicted protein
3 - - 37.4
164
Phosphatidylinositol glycan anchor biosynthesis class N
3 - - 11.8
156
Arylsulfatase
3 - - 1.2
163
Predicted protein
3 - - 65.2
150
N-sulfoglucosamine sulfohydrolase
sulfamidase
3 - - 24.5
147
Arylsulfatase
3 - - 11.9
148
Uncharacterized protein
3 - - 29.1
146
N-acetyl-galactosamine-6-sulfatase
GALNS
3 - - 5.8
158
Arylsulfatase
3 - - 10.1
165
Phosphatidylinositol glycan anchor biosynthesis class N
3 - - 8.3
157
Iduronate-2-sulfatase
3 - - 8.9
169
Predicted protein
3 - - 57.2
151
Predicted protein
3 - - 58.4
168
Iduronate-2-sulfatase and sulfatase 1
3 - - 34.2
167
Arylsulfatase family member H
3 - - 33.0
155
Iduronate-2-sulfatase
3 - - 10.2
159
Arylsulfatase
3 - - 7.6
161
Putative arylsulfatase
3 - - 1.2
144
Ectonucleotide pyrophosphatase/phosphodiesterase 2, short form
3 - - 46.1
173
Predicted protein
2 - - 22.6
231
Non-specific phospholipase C4
2 - - 34.7
211
Iduronate 2-sulfatase, putative
2 - - 1.2
223
Probable sulfatase atsG
2 - - 8.2
190
Uncharacterized protein
2 - - 10.7
196
Predicted protein
2 - - 38.0
217
Arylsulfatase A
2 - - 5.2
185
Iduronate-sulfatase
Partial
2 - - 1.0
218
N-acetylgalactosamine 6-sulfatase
GALNS
2 - - 9.7
172
Alkaline-phosphatase-like family protein
2 - - 17.4
224
Predicted protein
2 - - 33.7
189
Uncharacterized protein
2 - - 24.7
200
Choline sulfatase
2 - - 5.6
174
Uncharacterized protein
2 - - 33.7
222
N-acetylgalactosamine-6-sulfatase
2 - - 0.0
206
GPI ethanolamine phosphate transferase 2
2 - - 2.6
220
Arylsulfatase
2 - - 4.5
204
GM26188
2 - - 10.2
176
Predicted protein
2 - - 45.8
226
Uncharacterized protein
2 - - 20.3
181
Uncharacterized protein
2 - - 0.0
202
N-acetylgalactosamine 6-sulfate sulfatase
GALNS
2 - - 7.0
193
Putative ethanolamine phosphotransferase
2 - - 31.0
215
Arylsulfatase A
2 - - 7.0
188
Uncharacterized protein
2 - - 18.3
187
Uncharacterized protein
2 - - 21.6
194
Uncharacterized protein
2 - - 33.2
192
Uncharacterized protein
2 - - 29.8
235
Predicted protein
2 - - 40.2
219
Arylsulfatase A
2 - - 5.3
203
N-acetylgalactosamine 6-sulfate sulfatase
GALNS
2 - - 7.7
233
Predicted protein
2 - - 37.8
180
Arylsulfatase family member H
2 - - 2.3
209
Uncharacterized protein
2 - - 0.0
171
Bisphosphoglycerate-independent phosphoglycerate mutase family protein
2 - - 4.4
213
Iduronate-2-sulfatase
2 - - 5.0
221
Putative sulfatase yidJ
2 - - 1.5
186
Iduronate-2-sulfatase
2 - - 4.1
205
Metalloenzyme domain protein
2 - - 0.0
228
Uncharacterized protein
2 - - 0.8
199
Iduronate-2-sulfatase
2 - - 5.7
227
2,3-bisphosphoglycerate-independent phosphoglycerate mutase putative
2 - - 0.0
177
23-bisphosphoglycerate-independent phosphoglycerate mutase 1
2 - - 6.3
178
N-acetylgalactosamine-6-sulfatase
GALNS
2 - - 4.2
214
Choline-sulfatase
2 - - 6.5
232
Predicted protein
2 - - 32.5
195
Uncharacterized protein
2 - - 36.1
234
FI08016p
2 - - 37.6
212
Choline sulfatase
2 - - 5.2
236
Uncharacterized protein
2 - - 21.9
210
Uncharacterized protein
2 - - 1.1
216
DUF229 domain-containing protein
2 - - 0.0
183
Cell number regulator 8
2 - - 0.0
230
Arylsulfatase
A or B
2 - - 33.9
207
Putative glycosylphosphatidylinositol anchor synthesis protein
2 - - 3.2
208
Type I phosphodiesterase/nucleotide pyrophosphatase family protein
2 - - 7.0
191
Protein CBG24051
2 - - 30.6
225
Uncharacterized protein
2 - - 27.3
175
Alkaline-phosphatase-like family protein
2 - - 31.2
198
Uncharacterized protein
2 - - 10.1
184
Multifunctional alkaline phosphatase superfamily protein PehA
2 - - 2.4
229
Iduronate 2-sulfatase
Hunter syndrome
2 - - 22.9
197
Alkaline phosphatase
2 - - 11.0
182
DEAD-box ATP-dependent RNA helicase 18
2 - - 0.0
179
Uncharacterized protein
2 - - 0.0
201
Arylsulfatase
2 - - 0.0
245
Uncharacterized protein
1 - - 0.0
340
Uncharacterized protein
1 - - 0.0
357
Predicted protein
1 - - 0.0
260
Predicted protein
1 - - 0.0
327
Uncharacterized protein
1 - - 0.0
365
Uncharacterized protein HI_0841
1 - - 0.0
358
Predicted protein
1 - - 0.0
328
Uncharacterized protein HI_1316
1 - - 0.0
371
Predicted protein
1 - - 0.0
266
Iduronate-2-sulfatase
1 - - 0.0
346
Uncharacterized protein
1 - - 0.0
253
Uncharacterized protein
1 - - 0.0
285
Protein CBG09284
1 - - 0.0
380
Uncharacterized protein
1 - - 0.0
274
Uncharacterized protein
1 - - 0.0
369
Os03g0852800 protein
1 - - 0.0
332
Uncharacterized protein
1 - - 0.0
249
Uncharacterized protein
1 - - 0.0
314
Uncharacterized protein
1 - - 0.0
312
Uncharacterized protein
1 - - 0.0
272
Predicted protein
1 - - 0.0
334
Uncharacterized protein
1 - - 0.0
289
Uncharacterized protein
1 - - 0.0
378
Acid phosphatase
1 - - 0.0
309
Uncharacterized protein
1 - - 0.0
333
Uncharacterized protein
1 - - 0.0
377
Acid phosphatase
1 - - 0.0
273
Uncharacterized protein
1 - - 0.0
237
Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent, putative
1 - - 0.0
321
Iduronate-2-sulfatase
1 - - 0.0
351
Predicted protein
1 - - 0.0
313
Uncharacterized protein
1 - - 0.0
238
Predicted protein
1 - - 0.0
296
Putative phosphoethanolamine transferase HI_1064
1 - - 0.0
254
Uncharacterized protein
1 - - 0.0
305
Iduronate-2-sulfatase
1 - - 0.0
252
Arylsulfatase A
1 - - 0.0
290
Uncharacterized protein
1 - - 0.0
325
Predicted protein
1 - - 0.0
355
Uncharacterized protein
1 - - 0.0
250
Predicted protein
1 - - 0.0
292
WASH complex subunit 7-like Protein
1 - - 0.0
367
Uncharacterized protein
1 - - 0.0
247
Predicted protein
1 - - 0.0
368
Protein CBG04200
1 - - 0.0
248
Uncharacterized protein
1 - - 0.0
288
Uncharacterized protein
1 - - 0.0
256
Uncharacterized protein
1 - - 0.0
287
Uncharacterized protein
1 - - 0.0
294
Uncharacterized protein
1 - - 0.0
263
Predicted protein
1 - - 0.0
343
Uncharacterized protein
1 - - 0.0
359
Sulfatase 2
1 - - 0.0
329
Predicted protein
1 - - 0.0
301
Uncharacterized protein
1 - - 0.0
310
Uncharacterized protein
1 - - 0.0
336
Uncharacterized protein
1 - - 0.0
281
GPI ethanolamine phosphate transferase 2
1 - - 0.0
270
Predicted protein
1 - - 0.0
375
Uncharacterized protein
1 - - 0.0
330
Uncharacterized protein
1 - - 0.0
316
Predicted protein
1 - - 0.0
241
Uncharacterized protein
1 - - 0.0
361
Predicted protein
1 - - 0.0
276
Predicted protein
1 - - 0.0
308
Uncharacterized protein
1 - - 0.0
307
Uncharacterized protein
1 - - 0.0
344
Uncharacterized protein
1 - - 0.0
379
Predicted protein
1 - - 0.0
293
Chromosome 9, whole genome shotgun sequence
1 - - 0.0
264
Predicted protein
1 - - 0.0
382
Secreted ectonucleotide pyrophosphatase/phosphodiesterase, putative
1 - - 0.0
342
Alkaline phosphatase, biomineralization-associated
1 - - 0.0
239
Uncharacterized protein
1 - - 0.0
277
Predicted protein
1 - - 0.0
318
Uncharacterized protein
1 - - 0.0
278
Uncharacterized protein
1 - - 0.0
317
Uncharacterized protein
1 - - 0.0
338
Uncharacterized protein
1 - - 0.0
251
Sulfatase
1 - - 0.0
337
Uncharacterized protein
1 - - 0.0
373
Predicted protein
1 - - 0.0
299
Sulfatase and phosphatidylinositolglycan class N domain-containing protein
1 - - 0.0
300
Uncharacterized protein
1 - - 0.0
324
Uncharacterized protein
1 - - 0.0
354
N-acetylgalactosamine-6-sulfatase, putative
1 - - 0.0
306
Uncharacterized protein
1 - - 0.0
352
Uncharacterized protein
1 - - 0.0
322
Phosphatidylinositol-glycan biosynthesis, class O protein
1 - - 0.0
295
Uncharacterized protein
1 - - 0.0
258
Uncharacterized protein
1 - - 0.0
331
Uncharacterized protein
1 - - 0.0
286
Uncharacterized protein
1 - - 0.0
265
Predicted protein
1 - - 0.0
257
Uncharacterized protein
1 - - 0.0
360
Predicted protein
1 - - 0.0
240
Arylsulfatase H
1 - - 0.0
345
Ectonucleotide pyrophosphatase/phosphodiesterase, putative
1 - - 0.0
280
AGAP003222-PA
1 - - 0.0
323
Uncharacterized protein
1 - - 0.0
353
Uncharacterized protein
1 - - 0.0
311
Alkaline phosphatase
1 - - 0.0
246
Sulfatase
1 - - 0.0
366
Uncharacterized protein
1 - - 0.0
271
Uncharacterized protein
1 - - 0.0
349
Uncharacterized protein
1 - - 0.0
269
Predicted protein
1 - - 0.0
374
Arylsulfatase
1 - - 0.0
372
Arylsulfatase
1 - - 0.0
275
Sulfatase 1
1 - - 0.0
370
PhosphatidylInositol Glycan anchor biosynthesis class N homolog
1 - - 0.0
381
Phosphopentomutase
1 - - 0.0
315
Uncharacterized protein
1 - - 0.0
376
Predicted protein
1 - - 0.0
261
Uncharacterized protein
1 - - 0.0
341
Uncharacterized protein
1 - - 0.0
335
Iduronate-2-sulfatase
1 - - 0.0
282
Putative phosphoethanolamine transferase HI_1005
1 - - 0.0
364
Uncharacterized protein
1 - - 0.0
279
Predicted protein
1 - - 0.0
244
Arylsulfatase H
1 - - 0.0
319
Uncharacterized protein
1 - - 0.0
298
Predicted protein
1 - - 0.0
284
Uncharacterized protein
1 - - 0.0
339
Uncharacterized protein
1 - - 0.0
362
Uncharacterized protein HI_0841
1 - - 0.0
297
Uncharacterized protein
1 - - 0.0
242
Uncharacterized protein
1 - - 0.0
303
Uncharacterized protein
1 - - 0.0
348
Iduronate 2-sulfatase, putative
1 - - 0.0
268
Extracellular sulfatase SULF-1 homolog-like Protein
1 - - 0.0
347
Uncharacterized protein
1 - - 0.0
304
Predicted protein
1 - - 0.0
350
Sulfatase
1 - - 0.0
267
Predicted protein
1 - - 0.0
320
Arylsulfatase G
1 - - 0.0
283
Uncharacterized protein
1 - - 0.0
255
Alkaline-phosphatase-like family protein
1 - - 0.0
302
Uncharacterized protein
1 - - 0.0
243
Predicted protein
1 - - 0.0
363
Predicted protein
1 - - 0.0
326
Protein CBG15598
1 - - 0.0
356
Uncharacterized protein
1 - - 0.0
291
Uncharacterized protein
1 - - 0.0
259
Uncharacterized protein
1 - - 0.0
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