The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 106: Glutamate receptor ionotropic, kainate

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Kainate selective glutamate receptor activity GO:0015277
An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist.
13 A0A023GQ97 (/ISS) A0A0B4KHJ0 (/ISS) Q0KI38 (/ISS) Q0KIF2 (/ISS) Q5U168 (/ISS) Q8IM95 (/ISS) Q8MS48 (/ISS) Q9TVI0 (/ISS) Q9V4A0 (/ISS) Q9V4E9 (/ISS)
(3 more)
Ionotropic glutamate receptor activity GO:0004970
Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
2 Q0KI42 (/IC) Q9TVI0 (/IC)
Glutamate-gated calcium ion channel activity GO:0022849
Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
2 Q0KI42 (/IDA) Q9TVI0 (/IDA)
Glutamate-gated calcium ion channel activity GO:0022849
Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
2 Q9VDH5 (/IMP) Q9VDH5 (/IMP)
Ionotropic glutamate receptor activity GO:0004970
Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
1 Q9TVI0 (/IMP)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of synaptic activity GO:0060025
Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.
13 A0A023GQ97 (/ISS) A0A0B4KHJ0 (/ISS) Q0KI38 (/ISS) Q0KI42 (/ISS) Q0KIF2 (/ISS) Q5U168 (/ISS) Q8IM95 (/ISS) Q8MS48 (/ISS) Q9V4A0 (/ISS) Q9V4E9 (/ISS)
(3 more)
Regulation of membrane potential in photoreceptor cell GO:0016057
Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.
3 A0A023GQ97 (/IGI) Q0KIF2 (/IGI) Q9V4E9 (/IGI)
Regulation of membrane potential in photoreceptor cell GO:0016057
Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.
3 A0A023GQ97 (/IMP) Q0KIF2 (/IMP) Q9V4E9 (/IMP)
Synaptic transmission, glutamatergic GO:0035249
The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 A0A023GQ97 (/IGI) Q0KIF2 (/IGI) Q9V4E9 (/IGI)
Cellular response to light intensity GO:0071484
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
3 A0A023GQ97 (/IMP) Q0KIF2 (/IMP) Q9V4E9 (/IMP)
Optomotor response GO:0071632
Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish.
3 A0A023GQ97 (/IMP) Q0KIF2 (/IMP) Q9V4E9 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q0KI42 (/IDA) Q9TVI0 (/IDA)
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
2 Q0KI42 (/IEP) Q9TVI0 (/IEP)
Synaptic transmission, glutamatergic GO:0035249
The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 Q0KI42 (/IC) Q9TVI0 (/IC)
Calcium ion import across plasma membrane GO:0098703
The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.
2 Q9VDH5 (/IMP) Q9VDH5 (/IMP)
Positive regulation of neuromuscular synaptic transmission GO:1900075
Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission.
2 Q9VDH5 (/IMP) Q9VDH5 (/IMP)
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
1 Q9TVI0 (/IMP)
Rhythmic excitation GO:0043179
Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit.
1 Q9TVI0 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 A0A023GQ97 (/ISS) A0A0B4KHJ0 (/ISS) Q0KI38 (/ISS) Q0KIF2 (/ISS) Q5U168 (/ISS) Q8IM95 (/ISS) Q8MS48 (/ISS) Q9V4A0 (/ISS) Q9V4E9 (/ISS) Q9VDH2 (/ISS)
(2 more)
Ionotropic glutamate receptor complex GO:0008328
A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.
2 Q0KI42 (/IMP) Q9TVI0 (/IMP)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
2 Q9VDH5 (/IDA) Q9VDH5 (/IDA)
Muscle cell postsynaptic specialization GO:0097482
A postsynaptic specialization that is part of a neuromuscular junction.
2 Q0KI42 (/IDA) Q9TVI0 (/IDA)