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CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 119: Anthraniloyl-CoA anthraniloyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Anthraniloyl-CoA anthraniloyltransferase. [EC: 2.3.1.262]
Anthraniloyl-CoA + malonyl-CoA = 2-aminobenzoylacetyl-CoA + CoA + CO(2).
  • The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl- 3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone.
  • The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl- CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone.
  • However, when EC 3.1.2.32 is present, it removes the CoA moiety from the product, forming the stable 2-aminobenzoylacetate.
 4 A0A2X1XXZ6 A0A2X1XXZ6 P20582 P20582
Acyl-CoA:acyl-CoA alkyltransferase. [EC: 2.3.3.20]
2 an acyl-CoA + H(2)O = a (2R)-2-alkyl-3-oxoalkanoate + 2 CoA.
  • The enzyme, found in certain bacterial species, catalyzes a head- to-head non-decarboxylative Claisen condensation of two acyl-CoA molecules, resulting in formation of a 2-alkyl-3-oxoalkanoic acid.
  • It is part of a pathway for the production of olefins.
 1 Q8EG66