×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
3-ketoacyl-CoA thiolase
1064
3D
 5lp7H01 - 89.4
2
Acetyl-CoA acetyltransferase
930
3D
 5f38D02 - 95.9
3
3-ketoacyl-CoA thiolase
756
3D
 1pxtB02 - 94.2
5
3-oxoacyl-[acyl-carrier-protein] synthase I
543
3D
 2vbaD02 - 72.7
6
3-oxoacyl-[acyl-carrier-protein] synthase I
538
3D
 2vbaD01 - 76.2
4
3-oxoacyl-[acyl-carrier-protein] synthase 3
538 - - 96.2
14
Chalcone synthase 1
426
3D
 3tsyA03 - 99.3
8
3-hydroxy-3-methylglutaryl coenzyme A synthase
419
3D
 2fa3A00 - 91.8
7
acetyl-CoA acetyltransferase, mitochondrial
417 - - 86.7
9
3-oxoacyl-[acyl-carrier-protein] synthase 2
370 - - 92.3
10
Acetyl-CoA acetyltransferase
Thiolase
349 - - 92.5
25
Chalcone synthase 2
317
3D
 3tsyA02 - 96.5
12
3-ketoacyl-CoA thiolase, peroxisomal
294
3D
 1pxtB01 - 89.7
11
3-ketoacyl-CoA thiolase
292 - - 92.0
18
3-oxoacyl-[acyl-carrier-protein] synthase 2
273
3D
 5ld8B01 - 96.9
13
Acetyl-CoA acetyltransferase
262 - - 92.8
15
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
251
3D
 2iwzB02 - 90.2
19
Polyketide synthase type I
244
3D
 5erfB01 - 95.3
16
Non-specific lipid-transfer protein
235 - - 85.9
17
Acetyl-CoA acetyltransferase
225
3D
 4b3jD02 - 74.6
21
Fatty acid synthase subunit alpha
198
3D
 2uv8C05 - 84.7
20
Putative trifunctional enzyme subunit beta mitochondrial
197 - - 73.1
22
Acetyl-CoA acetyltransferase
179 - - 41.3
23
Acetyl-CoA acetyltransferase
177 - - 74.3
24
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
174
3D
 2ix4B01 - 90.7
29
3-oxoacyl-[acyl-carrier-protein] synthase 1
161
3D
 5ld8B02 - 93.9
26
3-oxoacyl-[acyl-carrier-protein] synthase 2
156 - - 52.1
27
3-oxoacyl-[acyl-carrier-protein] synthase 2
139 - - 80.2
30
Acetyl-CoA acetyltransferase
122
3D
 4b3jD01 - 72.9
33
Fatty acid synthase
121
3D
 5my0D01 - 72.3
32
Peroxisomal 3-ketoacyl-CoA thiolase
118
3D
 2wu9B00 - 77.8
28
3-ketoacyl-CoA synthase
118 - - 83.3
31
Sterigmatocystin biosynthesis polyketide synthase
112 - - 76.3
37
3-oxoacyl-ACP synthase III
109
3D
 6b2tB02 - 31.8
34
Acetyl-CoA acetyltransferase, cytosolic
106
3D
 1wl5A01 - 74.5
35
3-ketoacyl-CoA thiolase A, peroxisomal
84
3D
 2iikB00 - 65.7
36
3-oxoacyl-[acyl-carrier-protein] synthase II chloroplastic
80 - - 56.9
38
3-oxoacyl-[acyl-carrier-protein] synthase 2
69 - - 25.4
39
3-oxoacyl-[acyl-carrier-protein] synthase 2
68 - - 57.0
40
Type III polyketide synthase
64
3D
 1u0mB01 - 62.1
41
Lipid-transfer protein
62 - - 36.7
55
3-oxoacyl-ACP synthase III
62
3D
 6b2tB01 - 14.2
43
3-hydroxy-3-methylglutaryl CoA synthase
60
3D
 4yxqD01 - 76.8
53
Alpha-pyrone synthesis polyketide synthase
55
3D
 4jd3D01 - 60.4
45
Hydroxymethylglutaryl-CoA synthase
52
3D
 1xpkC02 - 66.0
42
Polyketide synthase Pks13
44
3D
 4wkyB01 - 90.6
50
3-oxoacyl-[acyl-carrier-protein] synthase 2
43
3D
 2rjtD02 - 18.8
71
3-oxoacyl-[acyl-carrier-protein] synthase 3
39
3D
 2qx1B02 - 23.9
44
Probable acetyl-CoA acyltransferase
39 - - 34.6
76
3-oxoacyl-[acyl-carrier-protein] synthase 3
39
3D
 2qx1B01 - 51.8
46
UPF0219 protein M1627_1703
35 - - 79.1
48
3-oxoacyl-Acyl-carrier-protein synthase III
34 - - 15.2
47
Acetyl-CoA acetyltransferase FadA6
34 - - 30.6
49
3-oxoacyl-Acyl-carrier-protein synthase III
33 - - 47.6
56
3-oxoacyl-[acyl-carrier-protein] synthase 3
33
3D
 4nhdD01 - 90.4
52
Beta-ketoacyl-acyl-carrier-protein synthase III
32 - - 11.3
51
3-oxoacyl-Acyl-carrier-protein synthase III
32 - - 53.6
54
Acetyl-CoA C-acetyltransferase VraB
31 - - 62.0
58
Acetyl-CoA C-acetyltransferase
27 - - 6.6
57
3-ketoacyl-CoA synthase
27 - - 60.6
59
Beta-ketoacyl-acyl-carrier-protein synthase II
23 - - 77.2
60
Acetyl-CoA acyltransferase 1
22 - - 44.3
61
Thiolase, C-terminal domain protein
22 - - 6.1
70
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
22
3D
 2iwzB01 - 31.9
85
2-heptyl-4
1H
22
3D
 6et3C02 - 0.0
62
Acetyl-CoA acetyltransferase FadA2
22 - - 27.5
68
3-oxoacyl-[acyl-carrier-protein] synthase 3
22
3D
 4nhdD02 - 35.5
63
Trifunctional enzyme subunit beta, mitochondrial
21 - - 24.3
64
Acetyl-CoA acetyltransferase FadA5
20 - - 21.7
122
Nonspecific lipid-transfer protein, putative
20
3D
 5ab7F00 - 1.1
65
Acetyl-CoA acyltransferase 1
19 - - 41.7
66
Fatty acid synthase subunit alpha, fungi type
19 - - 16.7
67
Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
18 - - 29.3
88
Putative chalcone synthase
17
3D
 3wy0B01 - 66.8
69
Acetyl-CoA C-acetyltransferase, putative
17 - - 54.7
74
Fatty acid synthase
15 - - 27.1
75
Acetyl-CoA acetyltransferase
15 - - 54.6
72
Thiolase
15 - - 18.7
73
Acetyl-CoA acetyltransferase
15 - - 82.4
77
3-oxoacyl-[acyl-carrier-protein] synthase 2
14 - - 14.7
105
Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
14
3D
 4yxvB02 - 0.0
89
Putative polyketide beta-ketoacyl synthase 2
14
3D
 1tqyH02 - 94.1
80
3-oxoacyl-[acyl-carrier protein] synthase II
13 - - 9.6
79
Acetyl-CoA acetyltransferase, putative
13 - - 8.4
78
Acetyl-CoA acetyltransferase FadA5
13 - - 12.8
104
Bisdemethoxycurcumin synthase
12
3D
 3oitB02 - 8.2
81
3-oxoacyl-[acyl-carrier-protein] synthase 2
12 - - 79.6
125
3-ketoacyl-CoA thiolase, mitochondrial
12
3D
 4c2kD02 - 37.4
87
3-oxoacyl-[acyl-carrier-protein] synthase 3
11 - - 0.0
84
Beta-keto-ACP synthase
11 - - 0.0
83
Probable acyl-CoA thiolase
11 - - 8.9
92
Alpha-pyrone synthesis polyketide synthase-like Pks18
11
3D
 1tedD01 - 0.0
82
GD13606
11 - - 32.1
86
3-hydroxy-3-methylglutaryl-CoA synthase, putative
11 - - 26.9
90
Lipid transfer protein or keto acyl-CoA thiolase Ltp2
10 - - 13.4
91
Probable polyketide synthase 32
10 - - 71.8
106
Actinorhodin polyketide putative beta-ketoacyl synthase 2
10
3D
 1tqyH01 - 15.6
119
Anthraniloyl-CoA anthraniloyltransferase
10
3D
 3h78B02 - 71.5
93
3-hydroxy-3-methylglutaryl coenzyme A synthase
9 - - 19.3
117
4-hydroxycoumarin synthase 1
9 - - 9.6
97
Acetyl-CoA acetyltransferase 2
8 - - 63.7
94
3-oxoacyl-[acyl-carrier-protein] synthase 2
8 - - 64.1
95
Uncharacterized protein
8 - - 17.9
107
3-oxoacyl-[acyl-carrier-protein] synthase 3
8
3D
 4x0oD00 - 0.0
98
Uncharacterized protein B0303.3
8 - - 45.7
96
Acetyl-CoA C-acetyltransferase
8 - - 17.7
102
Keto acyl-CoA thiolase
7 - - 0.0
99
3-oxoacyl-[acyl-carrier-protein] synthase 3
7 - - 5.2
101
Beta-ketoacyl synthase
7 - - 0.0
100
Beta-ketoacyl synthase, N-terminal domain protein
7 - - 9.9
108
Beta-ketoacyl-ACP synthase III
6 - - 2.7
110
Fatty acid synthase subunit alpha
6 - - 2.4
177
3-ketoacyl-CoA thiolase, putative
6
3D
 4bi9D00 - 0.0
109
2-heptyl-4
1H
6 - - 0.0
103
3,5-dihydroxyphenylacetyl-CoA synthase
6 - - 29.2
111
Uncharacterized protein
6 - - 28.8
116
GumO
5 - - 2.9
114
Uncharacterized protein
5 - - 12.3
115
Uncharacterized protein
5 - - 12.1
112
3-oxoacyl-
Acyl-carrier-protein
5 - - 37.2
113
Putative 3-oxoacyl-
Acyl-carrier-protein
5 - - 16.8
131
Uncharacterized protein
4 - - 34.3
129
3-hydroxy-3-methylglutaryl coenzyme A synthase
4 - - 49.5
127
Acetyl-CoA acetyltransferase, putative
4 - - 67.4
121
Beta-ketoacyl-ACP synthase II
4 - - 3.6
118
3-hydroxy-3-methylglutaryl coenzyme A synthase
4 - - 28.7
123
Putative hydroxymethylglutaryl-CoA synthase
4 - - 10.8
120
Uncharacterized protein
4 - - 1.2
130
3-oxoacyl-[acyl-carrier-protein] synthase 2
4 - - 27.9
128
Fatty acid synthase subunit beta
4 - - 39.9
124
Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4
4 - - 3.0
126
Protein CBG20965
4 - - 66.1
145
Polyketide synthase
3 - - 13.2
142
Hydroxymethylglutaryl-CoA synthase
3 - - 7.2
137
Protein CBG03789
3 - - 11.9
139
Polyketide beta-ketoacyl:acyl carrier proteinsynthase
3 - - 0.0
144
3 - - 0.0
146
Orsellinic acid synthase
3 - - 13.5
148
3 - - 19.9
133
3-hydroxy-3-methylglutaryl coenzyme A synthase
3 - - 0.4
143
Fatty acid synthase subunit beta
3 - - 37.1
138
3-oxoacyl-[acyl-carrier-protein] synthase 2
3 - - 3.2
140
Acetyl-CoA acetyltransferase
3 - - 0.0
147
Polyketide synthase type I
3 - - 0.7
141
Putative 3-oxoacyl-
Acyl-carrier-protein
3 - - 1.9
132
3 - - 78.0
135
Beta-ketoacyl synthase
3 - - 0.0
136
3 - - 14.1
134
Acetyl-CoA C-acyltransferase
3 - - 2.5
163
2 - - 0.0
187
2 - - 9.7
189
2 - - 8.3
152
3-ketoacyl-CoA-synthase
2 - - 3.7
155
2 - - 0.0
181
Beta ketoacyl-acyl carrier protein synthase
2 - - 0.0
178
3-oxoacyl-[acyl-carrier-protein] synthase
2 - - 0.0
160
Beta-ketoacyl synthase PigJ
2 - - 0.0
154
2 - - 9.3
199
2 - - 35.5
197
2 - - 10.2
191
Hydroxymethylglutaryl-CoA synthase
2 - - 2.3
156
2 - - 9.5
174
2 - - 40.5
193
2 - - 34.9
190
3-hydroxy-3-methylglutaryl coenzyme A synthase
2 - - 1.0
176
Trifunctional enzyme subunit beta, mitochondrial
2 - - 1.6
167
3-oxoacyl-
Acyl carrier protein
2 - - 0.0
183
3-oxoacyl-
Acyl-carrier-protein
2 - - 0.0
172
2 - - 21.3
169
3-oxoacyl-[acyl-carrier-protein] synthase
2 - - 21.3
175
2 - - 44.9
161
Putative polyketide beta-ketoacyl synthase 2
2 - - 5.7
158
2 - - 0.0
180
Acetyl-CoA acetyltransferase
2 - - 2.2
164
2 - - 0.0
166
3-oxoacyl-[acyl-carrier-protein] synthase, KASII
2 - - 6.6
198
2 - - 25.4
165
Fatty acid synthase, putative
JCVI
2 - - 0.0
153
2 - - 6.1
179
Predicted protein
2 - - 5.3
162
2 - - 0.0
188
2 - - 0.0
150
2 - - 27.5
171
2 - - 23.8
194
Polyketide synthase RzxE
2 - - 6.9
185
BIOTIN PIMELOYL-COA SYNTHESIS PROTEIN
2 - - 7.7
149
3-hydroxy-3-methylglutaryl coenzyme A synthase
2 - - 14.5
157
2 - - 4.0
173
2 - - 34.2
182
Thiolase
2 - - 0.0
159
2 - - 0.0
168
2 - - 9.0
170
3-hydroxy-3-methylglutaryl coenzyme A synthase
2 - - 9.1
196
Polyketide synthase, putative
JCVI
2 - - 0.0
151
Beta-ketoacyl synthase PigJ
2 - - 1.0
192
3-oxoacyl-[acyl-carrier-protein] synthase II
2 - - 3.7
200
2 - - 16.3
184
Acetoacetyl CoA synthase NphT7
2 - - 6.6
195
Amino acid adenylation domain protein
2 - - 0.3
186
3-oxoacyl-[acyl-carrier-protein] synthase 3
2 - - 0.0
229
1 - - 0.0
299
1 - - 0.0
310
Polyketide synthase
1 - - 0.0
244
1 - - 0.0
227
1 - - 0.0
297
1 - - 0.0
254
1 - - 0.0
256
1 - - 0.0
221
1 - - 0.0
291
1 - - 0.0
212
1 - - 0.0
246
1 - - 0.0
215
1 - - 0.0
255
1 - - 0.0
242
1 - - 0.0
231
1 - - 0.0
287
1 - - 0.0
216
1 - - 0.0
245
1 - - 0.0
263
1 - - 0.0
252
Acetyl-CoA C-acyltransferase
1 - - 0.0
301
1 - - 0.0
208
1 - - 0.0
289
1 - - 0.0
278
1 - - 0.0
237
1 - - 0.0
260
1 - - 0.0
214
1 - - 0.0
239
1 - - 0.0
307
Polyketide synthase RzxD
1 - - 0.0
309
Polyketide synthase/nonribosomal peptide synthetase hybrid RzxB
1 - - 0.0
281
Gll2853 protein
1 - - 0.0
275
1 - - 0.0
300
1 - - 0.0
283
1 - - 0.0
267
1 - - 0.0
230
1 - - 0.0
269
1 - - 0.0
272
1 - - 0.0
202
1 - - 0.0
258
1 - - 0.0
233
1 - - 0.0
280
1 - - 0.0
303
1 - - 0.0
248
Uncharacterized protein
1 - - 0.0
261
1 - - 0.0
205
1 - - 0.0
293
1 - - 0.0
223
1 - - 0.0
218
1 - - 0.0
206
1 - - 0.0
274
1 - - 0.0
204
1 - - 0.0
276
1 - - 0.0
220
1 - - 0.0
290
1 - - 0.0
277
1 - - 0.0
253
Uncharacterized protein
1 - - 0.0
238
1 - - 0.0
262
1 - - 0.0
279
1 - - 0.0
201
1 - - 0.0
308
Polyketide synthase/nonribosomal peptide synthetase hybrid RzxA
1 - - 0.0
243
1 - - 0.0
265
1 - - 0.0
240
1 - - 0.0
271
1 - - 0.0
209
1 - - 0.0
288
1 - - 0.0
250
3-hydroxy-3-methylglutaryl coenzyme A synthase
1 - - 0.0
207
1 - - 0.0
264
1 - - 0.0
210
1 - - 0.0
228
1 - - 0.0
298
1 - - 0.0
266
1 - - 0.0
213
1 - - 0.0
236
1 - - 0.0
295
1 - - 0.0
225
1 - - 0.0
284
1 - - 0.0
306
Probable polyketide synthase 37
1 - - 0.0
292
1 - - 0.0
222
1 - - 0.0
211
1 - - 0.0
304
Sterigmatocystin biosynthesis fatty acid synthase subunit alpha
1 - - 0.0
217
1 - - 0.0
286
1 - - 0.0
234
1 - - 0.0
219
1 - - 0.0
273
1 - - 0.0
257
1 - - 0.0
259
1 - - 0.0
282
1 - - 0.0
285
1 - - 0.0
247
3-oxoacyl-[acyl-carrier-protein] synthase
1 - - 0.0
224
1 - - 0.0
294
1 - - 0.0
249
Uncharacterized protein
1 - - 0.0
235
1 - - 0.0
251
Uncharacterized protein
1 - - 0.0
296
1 - - 0.0
302
1 - - 0.0
226
1 - - 0.0
305
Polyketide synthase
1 - - 0.0
268
1 - - 0.0
241
1 - - 0.0
232
1 - - 0.0
270
1 - - 0.0
203
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...