The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histidine kinase-like ATPase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Sensor histidine kinase RcsC

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
16 O14002 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA)
(6 more)
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
8 Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLN4 (/ISS) Q9KLN4 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O14002 (/IPI) P54302 (/IPI) P54302 (/IPI) Q87ID1 (/IPI) Q87ID1 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q87ID1 (/IPI) Q87ID1 (/IPI)
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
1 Q54U87 (/IMP)
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
1 Q9P7Q7 (/NAS)
Protein histidine kinase activity GO:0004673
Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
1 Q76H00 (/RCA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q54U87 (/TAS)
Transmembrane receptor histidine kinase activity GO:0009784
Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate.
1 Q54U87 (/IGI)
Transmembrane histidine kinase cytokinin receptor activity GO:0009885
Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate.
1 Q76H00 (/IDA)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 Q76H00 (/RCA)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
1 Q76H00 (/IDA)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
16 O14002 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA)
(6 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
16 P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP)
(6 more)
Single-species biofilm formation GO:0044010
A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
15 P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP)
(5 more)
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
15 P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP) P0DMC5 (/IMP)
(5 more)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
8 Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLK7 (/ISS) Q9KLN4 (/ISS) Q9KLN4 (/ISS)
Signal transduction by protein phosphorylation GO:0023014
A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
2 P54302 (/IGI) P54302 (/IGI)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 O14002 (/IMP) Q9P7Q7 (/IMP)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
1 Q9P7Q7 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q54U87 (/IGI)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
1 Q76H00 (/IDA)
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q76H00 (/IDA)
Regulation of protein kinase A signaling GO:0010738
Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
1 Q54RP6 (/IEP)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 Q54U87 (/IMP)
Sporulation resulting in formation of a cellular spore GO:0030435
The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
1 Q54U87 (/IMP)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q54U87 (/HMP)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q54U87 (/IMP)
Sorocarp stalk development GO:0031150
The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.
1 Q54U87 (/IMP)
Regulation of sorocarp development GO:0031156
Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum.
1 Q54RP6 (/IMP)
Sorocarp morphogenesis GO:0031288
The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.
1 Q54U87 (/IGI)
Positive regulation of stress-activated MAPK cascade GO:0032874
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
1 O14002 (/IMP)
Negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344
Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
1 Q54U87 (/TAS)
Detection of oxidative stress GO:0070994
The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal.
1 O14002 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
15 P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA) P0DMC5 (/IDA)
(5 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
15 P0DMC5 (/RCA) P0DMC5 (/RCA) P0DMC5 (/RCA) P0DMC5 (/RCA) P0DMC5 (/RCA) P0DMC5 (/RCA) P0DMC5 (/RCA) P0DMC5 (/RCA) P0DMC5 (/RCA) P0DMC5 (/RCA)
(5 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O14002 (/IDA) Q9P7Q7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9P7Q7 (/HDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q54U87 (/IDA)
Protein histidine kinase complex GO:0009365
A complex that possesses protein histidine kinase activity.
1 O14002 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q54U87 (/IDA)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q54U87 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q76H00 (/RCA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 Q9P7Q7 (/HDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
1 Q9P7Q7 (/HDA)