The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histidine kinase-like ATPase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1338
3D
6f1nA00 - 91.7
2
1069
3D
4i3hB01 - 81.0
3
738
3D
1nhjA01 - 90.7
4
691
3D
4r1fD01 - 91.8
5
630
3D
4nh9A00 - 93.0
7
469
3D
5m4pA02 - 83.9
6
435
3D
3sl2A00 - 97.1
9
398
3D
2iorA00 - 91.0
8
393
3D
1r62A00 - 71.6
10
342 - - 94.1
11
322
3D
4bizE02 - 91.3
12
308
3D
4x9lA00 - 67.0
13
296 - - 95.5
14
279
3D
3h4lB01 - 88.6
15
260 - - 71.4
16
254
3D
2ch4B01 - 92.6
19
223
3D
1id0A00 - 26.0
18
221
3D
4kp4B02 - 70.1
17
219 - - 97.0
21
218
3D
5tthA01 - 84.4
20
210 - - 46.1
22
191 - - 15.3
23
166 - - 95.2
24
162 - - 75.8
25
161 - - 53.6
26
155 - - 63.0
27
154 - - 79.0
28
151 - - 92.4
29
147 - - 26.8
30
146
3D
4pl9A00 - 92.4
31
144 - - 78.9
32
137 - - 93.3
33
133 - - 71.1
34
132
3D
4p7aA01 - 72.9
35
122 - - 70.4
36
118 - - 38.1
38
117 - - 70.9
37
117 - - 98.0
40
112 - - 51.4
39
112 - - 1.8
41
108 - - 83.0
42
108
3D
4gczB03 - 94.9
43
106 - - 67.1
44
98 - - 92.5
45
97 - - 63.8
46
91 - - 2.9
51
88
3D
4h85A02 - 31.2
47
85 - - 26.4
48
82 - - 20.1
49
81 - - 91.8
50
80 - - 70.3
52
74 - - 17.7
54
72
3D
3iedA00 - 86.7
53
72 - - 70.0
62
72
3D
2zbkH01 - 92.9
55
65
3D
3jz3B01 - 56.2
56
62 - - 21.3
57
61 - - 90.6
58
59 - - 7.9
59
56 - - 30.5
60
54 - - 29.8
61
53 - - 31.6
68
52
3D
1ysrC00 - 32.7
66
51
3D
6blkD00 - 82.7
63
ATP-hydrolyzing
50 - - 83.6
64
49 - - 79.8
65
Acetyl-transferring
47 - - 68.4
67
47 - - 85.2
71
45 - - 31.5
69
45 - - 73.9
70
45 - - 3.9
72
40 - - 27.2
73
34 - - 2.0
74
32 - - 40.2
76
32 - - 84.0
75
32 - - 91.2
77
31 - - 40.2
78
30 - - 93.7
80
29 - - 83.4
79
29 - - 81.3
81
28 - - 16.5
83
27 - - 71.4
82
27 - - 3.2
84
27 - - 8.1
85
26 - - 77.4
87
25 - - 75.3
86
25 - - 45.6
88
ATP-hydrolyzing
24 - - 80.1
91
23 - - 5.5
92
23 - - 88.0
89
23 - - 57.0
90
23 - - 4.7
94
22 - - 60.9
93
22 - - 1.4
95
21 - - 11.9
96
20 - - 35.2
97
20 - - 80.7
98
20 - - 0.0
99
20 - - 75.0
102
19 - - 1.5
357
19
3D
5ucjD00 - 13.6
103
19 - - 54.9
100
19 - - 1.6
101
19 - - 19.7
104
19 - - 71.5
109
18 - - 75.4
106
18 - - 20.8
107
18 - - 5.1
108
18 - - 59.2
105
18 - - 49.1
160
18
3D
6mfqB01 - 45.8
112
17 - - 2.2
111
17 - - 27.0
110
17 - - 14.6
113
16 - - 4.1
116
16 - - 34.0
114
16 - - 42.2
115
16 - - 27.0
117
15 - - 9.5
118
15 - - 28.7
119
15 - - 0.0
123
14 - - 0.0
126
14 - - 2.6
122
14 - - 11.0
124
14 - - 11.1
120
14 - - 11.0
125
14 - - 26.4
327
14
3D
6azrC02 - 5.1
121
14 - - 9.7
127
13 - - 6.9
128
13 - - 0.9
129
13 - - 6.8
133
13
3D
4bxiA00 - 6.1
146
13
3D
3zxoB00 - 35.2
130
13 - - 0.0
131
13 - - 44.2
229
13
3D
4fppC02 - 10.6
136
12 - - 26.9
132
12 - - 7.2
139
Mlh3
12 - - 63.7
235
12
3D
3gigB02 - 12.4
138
12 - - 0.0
137
12 - - 17.0
135
12 - - 18.2
134
12 - - 24.9
143
11 - - 9.0
148
11 - - 7.1
150
11 - - 56.1
147
11 - - 13.6
142
11 - - 10.4
204
11
3D
5fwkB01 - 31.6
149
11 - - 71.4
178
11
3D
3ke6B02 - 3.2
144
11 - - 49.8
141
11 - - 39.5
145
11 - - 14.6
140
11 - - 12.3
155
10 - - 0.8
230
10
3D
4q20B02 - 5.6
151
10 - - 8.4
154
10 - - 90.7
159
10 - - 73.0
156
10 - - 0.0
152
10 - - 0.0
157
10 - - 0.0
158
10 - - 11.5
153
10 - - 2.8
163
9 - - 48.2
168
9 - - 21.7
174
9 - - 17.4
167
9 - - 0.0
171
9 - - 6.8
180
9 - - 87.4
175
9 - - 16.2
166
9 - - 11.5
162
9 - - 0.0
170
9 - - 2.3
169
9 - - 0.0
173
9 - - 0.7
164
9 - - 10.3
177
9 - - 1.6
161
9 - - 13.7
172
9 - - 7.5
176
9 - - 55.2
165
9 - - 4.5
179
9 - - 5.9
201
AFU_orthologue AFUA_4G01020
8 - - 89.2
194
8 - - 16.5
200
8 - - 7.3
184
8 - - 9.2
185
8 - - 12.7
181
8 - - 0.0
195
8 - - 0.0
190
8 - - 0.8
191
8 - - 0.0
188
8 - - 44.0
202
8 - - 16.6
197
8 - - 0.0
183
8 - - 15.9
198
8 - - 0.0
187
8 - - 12.4
193
8 - - 6.2
199
8 - - 4.3
182
8 - - 11.1
186
8 - - 4.0
189
8 - - 7.3
192
8 - - 0.0
196
8 - - 0.0
205
Lipoamide
7 - - 42.1
214
7 - - 0.0
210
7 - - 0.0
215
7 - - 10.3
211
7 - - 0.9
213
7 - - 0.0
206
7 - - 14.5
209
7 - - 5.3
217
7 - - 83.9
216
7 - - 6.4
212
7 - - 0.0
203
7 - - 0.0
208
7 - - 0.0
207
7 - - 0.0
244
6 - - 81.8
224
6 - - 0.0
231
6 - - 0.0
234
6 - - 17.1
221
6 - - 0.0
220
6 - - 9.0
225
6 - - 0.0
240
6 - - 20.4
241
6 - - 6.3
223
6 - - 8.5
218
6 - - 6.7
228
6 - - 0.0
239
6 - - 1.5
227
6 - - 0.0
236
6 - - 18.4
232
6 - - 0.0
243
6 - - 11.1
237
6 - - 6.4
226
6 - - 0.0
222
6 - - 0.0
233
6 - - 0.0
242
6 - - 12.8
219
6 - - 0.0
238
6 - - 0.0
256
5 - - 0.0
264
5 - - 70.3
252
5 - - 1.6
259
5 - - 12.2
253
5 - - 7.9
258
5 - - 1.3
260
5 - - 0.0
257
5 - - 78.9
245
5 - - 0.0
265
5 - - 47.2
261
5 - - 15.8
251
5 - - 0.0
250
5 - - 11.6
267
5 - - 76.4
247
5 - - 1.2
255
5 - - 0.0
268
5 - - 58.1
248
5 - - 5.4
263
5 - - 40.3
249
5 - - 15.1
266
5 - - 70.7
254
5 - - 11.2
262
5 - - 7.1
246
5 - - 15.1
287
4 - - 0.0
293
4 - - 0.0
298
4 - - 9.5
277
4 - - 4.6
297
4 - - 10.9
278
4 - - 0.0
283
4 - - 0.8
273
4 - - 2.8
288
II
4 - - 20.4
279
4 - - 0.0
301
4 - - 61.0
289
4 - - 0.0
292
4 - - 12.7
300
4 - - 42.8
296
4 - - 1.3
272
4 - - 8.2
276
4 - - 0.9
299
4 - - 25.8
282
4 - - 0.8
286
4 - - 9.5
284
4 - - 0.0
274
4 - - 6.7
294
Acetyl-transferring
4 - - 8.2
291
4 - - 0.8
269
4 - - 1.5
295
4 - - 0.0
302
4 - - 80.5
290
One component system
4 - - 13.7
275
4 - - 7.9
281
4 - - 0.0
270
4 - - 65.0
271
4 - - 66.0
285
4 - - 0.0
280
4 - - 7.4
321
3 - - 1.3
334
3 - - 8.1
315
3 - - 2.4
353
3 - - 3.1
310
3 - - 35.5
325
3 - - 0.0
311
3 - - 41.2
320
3 - - 4.0
358
3 - - 9.5
340
3 - - 6.3
304
3 - - 0.8
345
3 - - 0.0
360
3 - - 3.5
361
Post Meiotic Segregation
3 - - 12.4
341
3 - - 0.0
364
3 - - 25.0
352
3 - - 9.6
356
3 - - 0.0
305
3 - - 6.3
344
3 - - 39.6
331
3 - - 9.7
324
3 - - 5.3
314
3 - - 9.4
359
3 - - 57.1
335
3 - - 0.0
330
3 - - 0.0
312
3 - - 12.5
303
3 - - 0.0
337
3 - - 0.0
349
3 - - 8.1
316
3 - - 0.0
322
3 - - 3.2
308
3 - - 6.7
326
3 - - 0.0
307
3 - - 9.8
346
3 - - 11.0
319
3 - - 0.0
354
3 - - 2.4
362
3 - - 1.1
342
3 - - 0.0
333
3 - - 0.0
329
3 - - 9.6
338
3 - - 5.5
351
3 - - 0.0
323
3 - - 0.0
318
3 - - 12.7
355
3 - - 9.6
339
3 - - 6.5
306
3 - - 4.1
347
One component system
3 - - 0.0
350
3 - - 7.1
313
3 - - 10.1
328
3 - - 1.3
348
3 - - 0.7
343
3 - - 38.3
332
3 - - 0.0
317
3 - - 0.0
309
3 - - 14.7
363
3 - - 3.6
336
3 - - 5.5
409
2 - - 0.0
417
2 - - 0.0
436
2 - - 0.0
463
2 - - 44.0
443
2 - - 10.4
379
2 - - 0.0
432
2 - - 4.0
396
2 - - 0.0
427
2 - - 27.0
392
2 - - 31.4
389
2 - - 7.8
448
2 - - 10.9
450
2 - - 2.0
365
2 - - 5.4
413
2 - - 3.5
402
2 - - 0.0
376
2 - - 0.0
428
2 - - 34.7
455
2 - - 10.3
439
One-component system
2 - - 0.0
372
2 - - 0.0
447
2 - - 4.4
406
2 - - 7.9
423
2 - - 2.4
386
2 - - 0.0
418
Hsp90 family
2 - - 21.1
451
2 - - 0.0
382
2 - - 6.5
399
2 - - 0.0
393
2 - - 0.0
438
2 - - 0.0
387
2 - - 0.0
429
2 - - 12.3
442
2 - - 0.0
377
2 - - 0.0
433
2 - - 2.2
398
2 - - 7.7
419
2 - - 0.0
446
2 - - 4.4
407
AFU_orthologue AFUA_4G00660
2 - - 0.0
454
2 - - 4.6
462
2 - - 43.0
426
Light-regulated signal transduction histidine kinase
2 - - 0.0
383
2 - - 0.0
378
2 - - 16.3
397
2 - - 10.8
408
2 - - 0.0
422
2 - - 1.5
437
2 - - 10.1
388
2 - - 0.0
373
2 - - 0.0
416
2 - - 15.8
449
2 - - 1.7
412
2 - - 0.0
403
2 - - 0.0
369
2 - - 0.0
430
2 - - 0.0
391
One-component system
2 - - 0.0
414
2 - - 4.3
459
2 - - 38.9
435
One-component system
2 - - 0.0
390
2 - - 0.0
395
2 - - 0.0
424
2 - - 0.0
431
2 - - 0.7
456
2 - - 0.0
405
2 - - 0.8
444
2 - - 0.0
370
2 - - 0.0
381
2 - - 9.1
464
2 - - 41.5
452
2 - - 5.8
366
2 - - 12.9
400
2 - - 0.0
375
2 - - 0.0
380
2 - - 0.0
401
2 - - 0.0
385
2 - - 8.5
371
2 - - 0.0
441
2 - - 2.5
384
2 - - 0.0
461
2 - - 38.2
404
2 - - 0.0
445
2 - - 0.0
460
2 - - 41.0
457
2 - - 46.7
367
2 - - 0.0
374
2 - - 0.0
440
2 - - 0.0
420
2 - - 0.7
458
2 - - 35.5
368
2 - - 0.0
425
2 - - 8.1
394
2 - - 0.0
411
2 - - 0.0
453
2 - - 7.8
410
2 - - 7.1
434
One-component system
2 - - 0.0
421
2 - - 0.0
415
2 - - 0.0
518
1 - - 0.0
523
1 - - 0.0
551
1 - - 0.0
468
1 - - 0.0
550
1 - - 0.0
528
1 - - 0.0
502
1 - - 0.0
513
1 - - 0.0
494
1 - - 0.0
539
1 - - 0.0
555
1 - - 0.0
547
1 - - 0.0
506
1 - - 0.0
467
1 - - 0.0
474
1 - - 0.0
527
1 - - 0.0
548
1 - - 0.0
509
1 - - 0.0
517
1 - - 0.0
536
1 - - 0.0
484
1 - - 0.0
563
1 - - 0.0
543
1 - - 0.0
532
1 - - 0.0
485
1 - - 0.0
537
1 - - 0.0
516
1 - - 0.0
549
1 - - 0.0
471
1 - - 0.0
480
1 - - 0.0
503
1 - - 0.0
512
1 - - 0.0
526
1 - - 0.0
481
1 - - 0.0
466
1 - - 0.0
475
1 - - 0.0
522
1 - - 0.0
508
1 - - 0.0
470
1 - - 0.0
495
1 - - 0.0
542
1 - - 0.0
533
1 - - 0.0
519
1 - - 0.0
546
1 - - 0.0
507
1 - - 0.0
490
1 - - 0.0
562
1 - - 0.0
554
1 - - 0.0
538
1 - - 0.0
491
1 - - 0.0
469
1 - - 0.0
529
1 - - 0.0
501
1 - - 0.0
473
1 - - 0.0
488
1 - - 0.0
556
1 - - 0.0
544
1 - - 0.0
505
1 - - 0.0
552
1 - - 0.0
478
1 - - 0.0
564
1 - - 0.0
483
1 - - 0.0
497
1 - - 0.0
500
1 - - 0.0
477
1 - - 0.0
524
1 - - 0.0
531
1 - - 0.0
498
1 - - 0.0
530
1 - - 0.0
514
1 - - 0.0
493
1 - - 0.0
535
1 - - 0.0
487
1 - - 0.0
559
1 - - 0.0
553
1 - - 0.0
482
1 - - 0.0
510
1 - - 0.0
499
1 - - 0.0
486
1 - - 0.0
534
1 - - 0.0
521
1 - - 0.0
515
1 - - 0.0
520
1 - - 0.0
472
1 - - 0.0
558
1 - - 0.0
525
1 - - 0.0
465
1 - - 0.0
511
1 - - 0.0
476
1 - - 0.0
492
1 - - 0.0
545
1 - - 0.0
504
1 - - 0.0
489
1 - - 0.0
557
1 - - 0.0
560
1 - - 0.0
540
1 - - 0.0
496
1 - - 0.0
565
1 - - 0.0
541
1 - - 0.0
479
1 - - 0.0
561
1 - - 0.0
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