The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Oligoribonuclease

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
119 P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA)
(109 more)
Single-stranded DNA 3'-5' exodeoxyribonuclease activity GO:0008310
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.
119 P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA)
(109 more)
Oligoribonucleotidase activity GO:0034611
Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates.
119 P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA)
(109 more)
Exoribonuclease activity GO:0004532
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
7 Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS)
3'-5' exonuclease activity GO:0008408
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
3 Q9Y3B8 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA)
3'-5' exonuclease activity GO:0008408
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
3 Q9Y3B8 (/TAS) Q9Y3B8 (/TAS) Q9Y3B8 (/TAS)
3'-5' exonuclease activity GO:0008408
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
2 P54964 (/ISS) Q556Y2 (/ISS)
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
1 P54964 (/IMP)
3'-5' exonuclease activity GO:0008408
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
1 Q9D8S4 (/ISO)
Oligonucleotidase activity GO:0008946
Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates.
1 Q9VCI0 (/ISS)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
119 P0A784 (/IMP) P0A784 (/IMP) P0A784 (/IMP) P0A784 (/IMP) P0A784 (/IMP) P0A784 (/IMP) P0A784 (/IMP) P0A784 (/IMP) P0A784 (/IMP) P0A784 (/IMP)
(109 more)
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
7 Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS) Q9KV17 (/ISS)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
3 Q9Y3B8 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA)
Nucleotide metabolic process GO:0009117
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
3 Q9Y3B8 (/TAS) Q9Y3B8 (/TAS) Q9Y3B8 (/TAS)
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
1 P54964 (/IGI)
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
1 P54964 (/IMP)
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000467
Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
1 P54964 (/IGI)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 Q9D8S4 (/ISO)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
1 O94626 (/ISS)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1 Q556Y2 (/IC)
U4 snRNA 3'-end processing GO:0034475
Any process involved in forming the mature 3' end of a U4 snRNA molecule.
1 P54964 (/IGI)
U4 snRNA 3'-end processing GO:0034475
Any process involved in forming the mature 3' end of a U4 snRNA molecule.
1 P54964 (/IMP)
U5 snRNA 3'-end processing GO:0034476
Any process involved in forming the mature 3' end of a U5 snRNA molecule.
1 P54964 (/IGI)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
119 P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA) P0A784 (/IDA)
(109 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 F5GYG5 (/IDA) F5GYG5 (/IDA) H0YG54 (/IDA) H0YG54 (/IDA) H0YG54 (/IDA) H0YGR4 (/IDA) P54964 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
9 F5GYG5 (/IDA) F5GYG5 (/IDA) H0YG54 (/IDA) H0YG54 (/IDA) H0YG54 (/IDA) H0YGR4 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
9 F5GYG5 (/IDA) F5GYG5 (/IDA) H0YG54 (/IDA) H0YG54 (/IDA) H0YG54 (/IDA) H0YGR4 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9Y3B8 (/IDA) Q9Y3B8 (/IDA) Q9Y3B8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 O94626 (/ISS) Q556Y2 (/ISS) Q9VCI0 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P54964 (/HDA) Q9D8S4 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O94626 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9D8S4 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9VCI0 (/ISS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9D8S4 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P54964 (/IMP)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D8S4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O94626 (/HDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q9D8S4 (/ISO)