The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 163: Exosome complex exonuclease RRP6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
1 Q12149 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q12149 (/IPI)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000467
Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
1 Q12149 (/IMP)
Posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery GO:0000973
The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.
1 Q12149 (/IMP)
U1 snRNA 3'-end processing GO:0034473
Any process involved in forming the mature 3' end of a U1 snRNA molecule.
1 Q12149 (/IGI)
U1 snRNA 3'-end processing GO:0034473
Any process involved in forming the mature 3' end of a U1 snRNA molecule.
1 Q12149 (/IMP)
U4 snRNA 3'-end processing GO:0034475
Any process involved in forming the mature 3' end of a U4 snRNA molecule.
1 Q12149 (/IGI)
U4 snRNA 3'-end processing GO:0034475
Any process involved in forming the mature 3' end of a U4 snRNA molecule.
1 Q12149 (/IMP)
U5 snRNA 3'-end processing GO:0034476
Any process involved in forming the mature 3' end of a U5 snRNA molecule.
1 Q12149 (/IGI)
U5 snRNA 3'-end processing GO:0034476
Any process involved in forming the mature 3' end of a U5 snRNA molecule.
1 Q12149 (/IMP)
Nuclear mRNA surveillance GO:0071028
The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nucleus.
1 Q12149 (/IMP)
Nuclear retention of pre-mRNA at the site of transcription GO:0071033
The process involved in retention of aberrant or improperly formed mRNAs, e.g. those that are incorrectly or incompletely spliced or that have incorrectly formed 3'-ends, within the nucleus at the site of transcription.
1 Q12149 (/IGI)
Nuclear polyadenylation-dependent rRNA catabolic process GO:0071035
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA.
1 Q12149 (/IGI)
Nuclear polyadenylation-dependent rRNA catabolic process GO:0071035
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA.
1 Q12149 (/IMP)
Nuclear polyadenylation-dependent snoRNA catabolic process GO:0071036
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA.
1 Q12149 (/IMP)
Nuclear polyadenylation-dependent snRNA catabolic process GO:0071037
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA.
1 Q12149 (/IMP)
Nuclear polyadenylation-dependent tRNA catabolic process GO:0071038
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA.
1 Q12149 (/IDA)
Nuclear polyadenylation-dependent tRNA catabolic process GO:0071038
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA.
1 Q12149 (/IGI)
Nuclear polyadenylation-dependent CUT catabolic process GO:0071039
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT.
1 Q12149 (/IGI)
Nuclear polyadenylation-dependent CUT catabolic process GO:0071039
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT.
1 Q12149 (/IMP)
Nuclear polyadenylation-dependent antisense transcript catabolic process GO:0071040
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript.
1 Q12149 (/IMP)
Nuclear polyadenylation-dependent mRNA catabolic process GO:0071042
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.
1 Q12149 (/IMP)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
1 Q12149 (/IMP)
Nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription GO:0071049
The process involved in retention of mRNAs that have incorrectly formed 3'-ends within the nucleus at the site of transcription.
1 Q12149 (/IGI)
Polyadenylation-dependent snoRNA 3'-end processing GO:0071051
Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA.
1 Q12149 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear exosome (RNase complex) GO:0000176
A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
1 Q12149 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q12149 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q12149 (/IDA)