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CATH Superfamily 2.40.70.10

Acid Proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 38: Plasmepsin-2

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Plasmepsin I. [EC: 3.4.23.38]
Hydrolysis of the 33-Phe-|-Leu-34 bond in the alpha-chain of hemoglobin, leading to denaturation of molecule.
  • Inhibited by pepstatin.
  • Belongs to peptidase family A1.
 121 A0A024VEN8 A0A024VEN8 A0A024VEN8 A0A024VEN8 A0A024VEN8 A0A024VEN8 A0A024VEN8 A0A024VEN8 A0A024VEN8 A0A024VEN8
(111 more...)
Plasmepsin II. [EC: 3.4.23.39]
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-|-Phe(NO(2))-Ser-Phe-Pro-Thr.
  • Inhibited by pepstatin.
  • Belongs to peptidase family A1.
 121 A0A024V0R3 A0A024V0R3 A0A024V0R3 A0A024V0R3 A0A024V0R3 A0A024V0R3 A0A024V0R3 A0A024V0R3 A0A024V0R3 A0A024V0R3
(111 more...)