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We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1845
3D
6e9aB00 - 89.6
3
921
3D
6fgyA02 - 90.0
7
836
3D
6fgyA01 - 84.9
24
652
3D
1ibqB02 - 91.5
26
649
3D
1ibqB01 - 94.2
2
389
3D
2jxrA02 - 95.3
4
343
3D
1htrB01 - 96.5
5
319
3D
4rghB00 - 83.6
6
282
3D
1tzsA02 - 95.5
32
252
3D
6i3fB01 - 79.6
37
246
3D
6i3fB02 - 79.6
9
187
3D
5nfgB01 - 81.4
8
186 - - 96.2
11
169
3D
2qzwB01 - 91.4
35
160
3D
5yieA01 - 80.6
38
156
3D
5yieA02 - 81.2
10
146 - - 90.7
12
145 - - 86.7
13
145 - - 95.8
14
144 - - 94.1
15
137 - - 92.9
23
123
3D
2qzwB02 - 96.9
16
118 - - 89.2
17
117 - - 91.5
18
116 - - 89.2
19
112 - - 76.8
20
110 - - 74.4
21
108 - - 94.0
22
105 - - 87.4
25
93 - - 77.6
27
90 - - 91.1
28
89 - - 84.1
29
87 - - 91.1
36
86
3D
2jxrA01 - 84.9
39
83
3D
4od9C00 - 38.8
30
82 - - 71.0
31
82 - - 92.5
33
75 - - 98.3
34
74 - - 95.2
45
74
3D
4pphF01 - 93.1
47
70
3D
4od9D00 - 54.3
41
70
3D
3vlbC02 - 95.5
40
67 - - 83.1
44
66
3D
5n7qB02 - 60.3
43
62 - - 33.9
42
62 - - 90.8
46
61 - - 78.9
48
57 - - 82.5
49
56 - - 94.8
50
53 - - 96.8
51
50 - - 88.3
52
49 - - 86.9
152
46
3D
4ydgB00 - 5.6
54
46 - - 35.3
53
46 - - 65.6
56
42 - - 78.6
57
42 - - 82.1
55
42 - - 84.1
58
38 - - 97.9
60
34 - - 93.2
59
34 - - 39.2
61
33 - - 77.5
62
32 - - 71.3
72
31
3D
4z2zB00 - 78.8
63
31 - - 71.0
64
30 - - 75.4
87
29
3D
3nr6B00 - 23.5
66
29 - - 85.2
65
29 - - 76.2
75
29
3D
3hd8C01 - 84.0
67
28 - - 77.3
70
26 - - 80.1
69
26 - - 85.3
68
OpsB
26 - - 87.1
71
25 - - 61.5
73
25 - - 82.3
74
24 - - 79.0
77
22 - - 87.9
76
22 - - 7.5
84
21 - - 77.9
81
21 - - 5.8
80
21 - - 82.2
126
21
3D
4pphF02 - 79.0
79
21 - - 71.5
78
21 - - 78.5
83
21 - - 74.6
82
21 - - 3.4
86
20 - - 82.9
85
CtsD
20 - - 90.3
90
19 - - 82.6
88
19 - - 88.0
89
19 - - 87.9
91
18 - - 80.1
92
AP1
17 - - 67.8
93
17 - - 0.0
94
16 - - 73.7
97
16 - - 38.5
96
16 - - 92.8
101
16 - - 85.9
95
16 - - 90.2
100
16 - - 90.6
99
16 - - 5.0
98
16 - - 73.5
102
15 - - 84.5
115
15
3D
1b5fC00 - 37.6
104
14 - - 82.4
108
14 - - 6.8
103
14 - - 18.6
107
14 - - 16.3
106
14 - - 10.1
105
14 - - 62.2
114
13 - - 76.1
111
13 - - 0.0
113
13 - - 90.7
109
13 - - 28.2
112
13 - - 0.0
110
13 - - 13.6
118
12 - - 32.4
120
12 - - 71.5
122
12 - - 3.0
117
12 - - 90.6
119
12 - - 40.7
123
12 - - 87.4
116
12 - - 79.7
121
12 - - 37.2
151
12
3D
2rspB00 - 3.7
130
11 - - 88.0
132
11 - - 75.3
125
11 - - 47.5
131
11 - - 97.2
129
11 - - 34.7
127
11 - - 9.8
124
11 - - 0.9
128
11 - - 3.9
135
10 - - 46.4
136
10 - - 16.0
133
10 - - 76.8
137
10 - - 36.1
139
S5
10 - - 4.0
134
10 - - 71.6
138
10 - - 41.0
140
10 - - 9.5
148
9 - - 90.3
144
9 - - 6.0
147
9 - - 1.1
149
9 - - 86.9
141
9 - - 73.5
143
9 - - 15.2
142
9 - - 34.2
145
9 - - 7.8
146
9 - - 2.2
161
8 - - 0.0
155
8 - - 35.4
163
8 - - 63.6
156
8 - - 17.3
150
8 - - 9.8
158
8 - - 5.1
160
8 - - 8.8
154
8 - - 62.4
157
8 - - 3.9
159
8 - - 7.4
153
8 - - 44.4
162
8 - - 70.7
174
7 - - 74.9
167
7 - - 92.6
169
7 - - 17.9
173
7 - - 56.0
168
7 - - 5.3
164
7 - - 13.0
171
7 - - 89.2
172
7 - - 18.2
170
7 - - 9.4
166
7 - - 82.9
165
7 - - 0.9
180
6 - - 65.3
178
6 - - 6.4
182
6 - - 85.6
185
6 - - 3.4
186
6 - - 75.0
177
6 - - 6.0
179
6 - - 53.2
176
6 - - 41.8
175
6 - - 86.0
183
6 - - 8.0
187
6 - - 67.0
181
6 - - 56.1
184
6 - - 14.6
188
6 - - 80.9
205
5 - - 13.5
190
5 - - 72.0
202
5 - - 81.7
206
5 - - 9.1
215
5 - - 62.3
212
5 - - 11.2
216
5 - - 92.9
196
5 - - 30.7
195
5 - - 36.1
200
5 - - 78.2
192
5 - - 12.7
210
5 - - 3.4
193
5 - - 18.2
204
5 - - 25.1
189
5 - - 17.3
199
5 - - 70.4
208
5 - - 6.6
197
5 - - 72.7
191
5 - - 74.4
214
5 - - 79.6
211
5 - - 14.7
194
5 - - 0.9
217
5 - - 82.0
203
5 - - 89.5
201
5 - - 81.1
209
5 - - 6.2
207
5 - - 10.2
198
5 - - 86.3
213
5 - - 56.6
233
4 - - 1.5
223
4 - - 76.5
229
4 - - 70.8
227
4 - - 87.7
246
4 - - 86.7
221
4 - - 53.8
245
4 - - 33.8
242
4 - - 0.6
231
4 - - 24.3
237
4 - - 3.6
239
4 - - 1.7
234
4 - - 12.3
224
4 - - 19.0
251
4 - - 78.3
238
4 - - 5.0
240
4 - - 8.6
228
4 - - 75.4
230
4 - - 20.3
248
4 - - 82.2
218
4 - - 64.3
220
4 - - 77.2
244
4 - - 49.9
252
4 - - 31.9
222
4 - - 15.5
236
4 - - 6.6
225
4 - - 74.5
219
4 - - 0.0
247
4 - - 49.0
249
4 - - 12.8
241
4 - - 0.6
232
4 - - 4.1
235
4 - - 12.3
226
4 - - 73.6
243
4 - - 7.6
250
4 - - 73.9
283
3 - - 0.7
272
3 - - 3.6
275
3 - - 0.0
258
3 - - 43.4
276
3 - - 1.2
254
3 - - 0.0
287
3 - - 1.5
289
3 - - 47.6
281
3 - - 7.7
260
3 - - 22.8
284
3 - - 12.0
257
3 - - 43.4
259
3 - - 26.5
270
3 - - 9.9
265
3 - - 1.9
253
3 - - 3.3
262
3 - - 32.9
288
3 - - 66.6
266
3 - - 13.5
267
3 - - 1.2
269
3 - - 9.8
261
3 - - 35.4
280
3 - - 0.0
274
3 - - 0.0
256
3 - - 0.0
263
3 - - 8.9
255
3 - - 1.0
278
3 - - 0.0
286
3 - - 0.0
285
3 - - 0.0
273
3 - - 10.5
282
3 - - 5.2
268
3 - - 2.9
277
3 - - 0.0
279
3 - - 11.0
271
3 - - 11.1
264
3 - - 8.7
394
2 - - 0.0
324
2 - - 0.0
359
2 - - 0.0
434
2 - - 13.1
300
2 - - 30.5
357
2 - - 0.0
370
2 - - 2.4
351
2 - - 0.0
384
2 - - 0.0
293
2 - - 23.4
400
2 - - 24.3
334
2 - - 0.0
424
2 - - 26.6
299
2 - - 29.0
310
2 - - 40.1
297
2 - - 0.0
366
2 - - 0.0
398
2 - - 2.4
328
2 - - 0.0
291
2 - - 0.0
428
2 - - 36.9
365
2 - - 0.0
362
2 - - 6.2
338
2 - - 0.7
353
2 - - 0.0
410
2 - - 0.0
388
2 - - 0.0
340
2 - - 0.0
402
2 - - 19.2
306
2 - - 39.2
433
2 - - 40.3
323
2 - - 0.0
393
2 - - 0.0
405
2 - - 0.0
376
2 - - 0.0
294
2 - - 36.7
372
2 - - 10.1
383
2 - - 0.0
375
2 - - 0.0
305
2 - - 37.3
423
2 - - 0.0
406
2 - - 0.0
302
2 - - 32.5
358
2 - - 0.9
333
2 - - 0.0
421
2 - - 0.0
389
2 - - 0.0
316
2 - - 0.0
412
2 - - 3.2
387
2 - - 0.0
345
2 - - 0.0
342
2 - - 0.0
331
2 - - 0.7
415
2 - - 0.0
381
2 - - 0.0
429
2 - - 22.1
427
2 - - 35.3
339
2 - - 0.0
360
2 - - 0.0
337
2 - - 1.4
354
2 - - 8.2
397
2 - - 0.0
327
2 - - 0.0
399
2 - - 4.4
329
2 - - 0.0
346
2 - - 0.0
431
2 - - 35.8
315
2 - - 28.8
312
2 - - 16.6
416
2 - - 0.0
298
2 - - 3.0
391
2 - - 9.4
321
2 - - 0.0
349
2 - - 4.1
385
2 - - 4.9
347
2 - - 0.0
382
2 - - 0.0
417
2 - - 0.0
373
2 - - 0.0
419
2 - - 37.0
341
2 - - 0.0
332
2 - - 0.0
436
2 - - 39.0
303
2 - - 33.9
425
2 - - 17.8
368
2 - - 8.6
422
2 - - 1.2
326
2 - - 0.0
396
2 - - 2.6
411
2 - - 0.0
335
2 - - 0.0
311
2 - - 37.4
435
2 - - 35.7
426
2 - - 25.9
322
2 - - 0.7
392
2 - - 8.1
325
2 - - 0.7
395
2 - - 0.0
336
2 - - 0.0
432
2 - - 40.1
403
2 - - 35.8
319
2 - - 0.0
290
2 - - 3.1
386
2 - - 0.0
317
2 - - 7.2
409
2 - - 43.5
364
2 - - 10.5
407
2 - - 0.0
313
2 - - 15.0
401
2 - - 17.1
301
2 - - 32.2
343
2 - - 0.0
379
2 - - 0.6
413
2 - - 7.6
377
2 - - 9.4
350
2 - - 0.0
307
2 - - 38.1
309
2 - - 43.4
371
2 - - 0.0
292
2 - - 54.3
374
2 - - 0.0
318
2 - - 0.0
295
2 - - 2.1
390
2 - - 0.0
320
2 - - 0.0
430
2 - - 34.2
304
2 - - 34.2
369
2 - - 3.5
404
2 - - 0.0
330
2 - - 0.0
367
2 - - 0.0
420
2 - - 0.0
361
2 - - 0.0
348
2 - - 0.0
418
2 - - 0.0
380
2 - - 0.0
296
2 - - 8.0
352
2 - - 0.0
308
2 - - 17.4
363
2 - - 4.0
355
2 - - 10.6
314
2 - - 19.2
378
2 - - 8.3
414
2 - - 0.0
344
2 - - 0.8
356
2 - - 5.5
408
2 - - 37.2
540
1 - - 0.0
562
1 - - 0.0
538
1 - - 0.0
553
1 - - 0.0
484
1 - - 0.0
565
1 - - 0.0
528
1 - - 0.0
451
1 - - 0.0
470
1 - - 0.0
566
1 - - 0.0
510
1 - - 0.0
457
1 - - 0.0
459
1 - - 0.0
494
1 - - 0.0
440
1 - - 0.0
488
1 - - 0.0
534
1 - - 0.0
584
1 - - 0.0
438
1 - - 0.0
453
1 - - 0.0
462
1 - - 0.0
465
1 - - 0.0
551
1 - - 0.0
498
1 - - 0.0
570
1 - - 0.0
466
1 - - 0.0
559
1 - - 0.0
557
1 - - 0.0
500
1 - - 0.0
524
1 - - 0.0
458
1 - - 0.0
512
1 - - 0.0
521
1 - - 0.0
515
1 - - 0.0
546
1 - - 0.0
475
1 - - 0.0
527
1 - - 0.0
529
1 - - 0.0
483
1 - - 0.0
554
1 - - 0.0
472
1 - - 0.0
560
1 - - 0.0
539
1 - - 0.0
476
1 - - 0.0
537
1 - - 0.0
581
1 - - 0.0
542
1 - - 0.0
531
1 - - 0.0
493
1 - - 0.0
545
1 - - 0.0
516
1 - - 0.0
491
1 - - 0.0
558
1 - - 0.0
533
1 - - 0.0
502
1 - - 0.0
505
1 - - 0.0
446
1 - - 0.0
499
1 - - 0.0
497
1 - - 0.0
575
1 - - 0.0
572
1 - - 0.0
454
1 - - 0.0
583
1 - - 0.0
437
1 - - 0.0
460
1 - - 0.0
576
1 - - 0.0
439
1 - - 0.0
481
1 - - 0.0
523
1 - - 0.0
442
1 - - 0.0
487
1 - - 0.0
506
1 - - 0.0
445
1 - - 0.0
489
1 - - 0.0
571
1 - - 0.0
507
1 - - 0.0
486
1 - - 0.0
550
1 - - 0.0
509
1 - - 0.0
579
1 - - 0.0
495
1 - - 0.0
577
1 - - 0.0
492
1 - - 0.0
543
1 - - 0.0
501
1 - - 0.0
496
1 - - 0.0
468
1 - - 0.0
441
1 - - 0.0
513
1 - - 0.0
473
1 - - 0.0
564
1 - - 0.0
482
1 - - 0.0
485
1 - - 0.0
447
1 - - 0.0
449
1 - - 0.0
471
1 - - 0.0
519
1 - - 0.0
517
1 - - 0.0
450
1 - - 0.0
477
1 - - 0.0
525
1 - - 0.0
479
1 - - 0.0
536
1 - - 0.0
443
1 - - 0.0
511
1 - - 0.0
522
1 - - 0.0
526
1 - - 0.0
535
1 - - 0.0
503
1 - - 0.0
541
1 - - 0.0
532
1 - - 0.0
568
1 - - 0.0
582
1 - - 0.0
464
1 - - 0.0
573
1 - - 0.0
549
1 - - 0.0
547
1 - - 0.0
480
1 - - 0.0
556
1 - - 0.0
448
1 - - 0.0
461
1 - - 0.0
544
1 - - 0.0
467
1 - - 0.0
469
1 - - 0.0
514
1 - - 0.0
578
1 - - 0.0
490
1 - - 0.0
555
1 - - 0.0
508
1 - - 0.0
552
1 - - 0.0
563
1 - - 0.0
474
1 - - 0.0
456
1 - - 0.0
580
1 - - 0.0
561
1 - - 0.0
548
1 - - 0.0
444
1 - - 0.0
530
1 - - 0.0
569
1 - - 0.0
567
1 - - 0.0
478
1 - - 0.0
504
1 - - 0.0
520
1 - - 0.0
455
1 - - 0.0
574
1 - - 0.0
463
1 - - 0.0
452
1 - - 0.0
518
1 - - 0.0
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