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CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Serine endoprotease DegS, periplasmic

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
 111 P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS)
(101 more)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
 110 P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP)
(100 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 110 P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI)
(100 more)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
 110 P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP)
(100 more)
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
 110 P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP)
(100 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 110 P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI) P0AEE3 (/IPI)
(100 more)
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
 12 A0A0F7R9Y9 (/ISS) A0A0F7R9Y9 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS)
(2 more)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
 7 Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS) Q9KUF6 (/ISS)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
 167 D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP)
(157 more)
Cellular response to misfolded protein GO:0071218
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
 111 P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS)
(101 more)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
 110 P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA)
(100 more)
Cellular response to misfolded protein GO:0071218
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
 110 P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP)
(100 more)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
 57 D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP)
(47 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
 57 D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP) D0ZY51 (/IMP)
(47 more)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
 19 A0A0F7R9Y9 (/ISS) A0A0F7R9Y9 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS) A0A2B6C4K2 (/ISS)
(9 more)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
 111 P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS) P0AEE4 (/ISS)
(101 more)
Outer membrane-bounded periplasmic space GO:0030288
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
 110 P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA) P0AEE3 (/IDA)
(100 more)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
 110 P0AEE3 (/RCA) P0AEE3 (/RCA) P0AEE3 (/RCA) P0AEE3 (/RCA) P0AEE3 (/RCA) P0AEE3 (/RCA) P0AEE3 (/RCA) P0AEE3 (/RCA) P0AEE3 (/RCA) P0AEE3 (/RCA)
(100 more)
Integral component of external side of plasma membrane GO:0071575
The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane.
 110 P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP) P0AEE3 (/IMP)
(100 more)