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CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Tryptase beta-2

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tryptase. [EC: 3.4.21.59]
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
  • Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules.
  • Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin.
  • Belongs to peptidase family S1.
 18 A1Z090 A1Z090 B5A5B2 B5A5B2 P15944 P20231 P20231 P21845 P21845 P27435
(8 more...)