CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1280 | Alpha/beta knot |
|
3.40.1280.10 | SPOUT methyltransferase, trefoil knot domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.1280.10 |
| Functional Family | Ribosomal RNA large subunit methyltransferase H |
Enzyme Information
| 2.1.1.177 |
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase.
based on mapping to UniProt P0A8I8
S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L- homocysteine + N(3)-methylpseudouridine(1915) in 23S rRNA.
-!- YbeA does not methylate uridine at position 1915.
|
UniProtKB Entries (1)
| P0A8I8 |
RLMH_ECOLI
Escherichia coli K-12
Ribosomal RNA large subunit methyltransferase H
|
PDB Structure
| PDB | 5TWK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine.
Sci Rep
|
