CATH Superfamily 3.40.1280.10
SPOUT methyltransferase, trefoil knot domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
The TrmH structure has a disc-like shape, composed of a major catalytic domain and a helical subdomain. The catalytic domain consists of a parallel six-stranded beta-sheet, which is flanked by two alpha-helices on one side and by four alpha-helices on the other side. The N-terminal half of the catalytic domain resembles a Rossmann fold or consensus MTase fold, while the C-terminal half has a different topology as compared with that of the consensus MTase fold: it includes a deep trefoil knot. The helical subdomain consists of the N-terminal helix 1 and the C-terminal helix 8, which interact with each other.
Pfam [PfamClan:CL0098], INTERPRO:IPR029026, INTERPRO:IPR029028,PMID:24951554,PMID:15062082
|Domain clusters (>95% seq id):||64|
|Domain clusters (>35% seq id):||34|
|Structural Clusters (5A):||5|
|Structural Clusters (9A):||3|