CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Metabotropic glutamate receptor 3

Enzyme Information

UniProtKB Entries (1)

Q14832
GRM3_HUMAN
Homo sapiens
Metabotropic glutamate receptor 3

PDB Structure

PDB 5CNK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
Monn, J.A., Prieto, L., Taboada, L., Hao, J., Reinhard, M.R., Henry, S.S., Beadle, C.D., Walton, L., Man, T., Rudyk, H., Clark, B., Tupper, D., Baker, S.R., Lamas, C., Montero, C., Marcos, A., Blanco, J., Bures, M., Clawson, D.K., Atwell, S., Lu, F., Wang, J., Russell, M., Heinz, B.A., Wang, X., Carter, J.H., Getman, B.G., Catlow, J.T., Swanson, S., Johnson, B.G., Shaw, D.B., McKinzie, D.L.
J.Med.Chem.