CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family PTS system fructose-like transporter subunit IIB

Enzyme Information

2.7.1.202
Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase.
based on mapping to UniProt P71012
[Protein]-N(pi)-phospho-L-histidine + D-fructose(Side 1) = [protein]-L- histidine + D-fructose 1-phosphate(Side 2).
-!- This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). -!- The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. -!- The phosphate donor, which is shared among the different systems, is usually a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9. -!- The enzyme from the bacterium Escherichia coli is an exception, since it is phosphorylated directly by EC 2.7.3.9. -!- The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. -!- Formerly EC 2.7.1.69.

UniProtKB Entries (1)

P71012
PTF3A_BACSU
Bacillus subtilis subsp. subtilis str. 168
PTS system fructose-specific EIIABC component

PDB Structure

PDB 2R4Q
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of a domain of fruA from Bacillus subtilis.
Cuff, M.E., Sather, A., Nocek, B., Clancy, S., Joachimiak, A.
TO BE PUBLISHED