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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36574: Putative glyoxylate carboligase protein

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tartronate-semialdehyde synthase. [EC: 4.1.1.47]
2 glyoxylate = tartronate semialdehyde + CO(2).
    		 2402 A0A010RMT6 A0A010RMT6 A0A011URZ0 A0A011URZ0 A0A011VFI5 A0A011VFI5 A0A016XEJ1 A0A016XEJ1 A0A017IMH9 A0A017IMH9
    (2392 more...)
    Acetolactate synthase. [EC: 2.2.1.6]
    2 pyruvate = 2-acetolactate + CO(2).
    • The reaction shown is in the pathway of biosynthesis of valine.
    • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
    • Formerly EC 4.1.3.18.
    		 12 A0A0T8KYE7 A0A0T8KYE7 A0A1C2H183 A0A1C2H183 A0A1M3Z2C2 A0A1M3Z2C2 A0A1M3ZRQ5 A0A1M3ZRQ5 A4VP51 A4VP51
    (2 more...)
    Nicotinamide-nucleotide adenylyltransferase. [EC: 2.7.7.1]
    ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).
    • Nicotinate nucleotide can also act as acceptor.
    • See also EC 2.7.7.18.
    		 2 C4WIL2 C4WIL2
    GTP cyclohydrolase I. [EC: 3.5.4.16]
    GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)-dihydropteridine triphosphate.
    • The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic.
    • Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.
    		 2 G8Q3D0 G8Q3D0