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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
36569
1-deoxyxylulose-5-phosphate synthase transketolase
37391
EC
3D
 3mosA02 - 97.8
36536
2-oxoglutarate dehydrogenase E1 component
30791
EC
3D
 1ni4A00 - 91.7
36565
Transketolase 1, thiamin-binding protein
22974
EC
3D
 1ay0A01 - 94.0
36590
1-deoxy-D-xylulose-5-phosphate synthase 1, chloroplastic
21195
EC
3D
 1l8aA01 - 96.3
36455
Acetolactate synthase large subunit
20861
EC
3D
 1jscA01 - 98.1
36407
Acetolactate synthase large subunit
20103
EC
3D
 1jscA03 - 98.4
36356
Pyruvate dehydrogenase beta subunit
16974
EC
3D
 1ni4B01 - 90.5
36519
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
7113
EC
3D
 2jlaA01 - 96.9
35890
Pyruvate dehydrogenase E1 component
6832
EC
3D
 1l8aA02 - 88.6
36507
Probable 2-hydroxyacyl-CoA lyase 1
6302
EC
3D
 2q27A03 - 92.9
35932
Putative pyruvate-flavodoxin oxidoreductase domain protein
5797
EC
3D
 1b0pA01 - 96.5
36363
Acetolactate synthase large subunit
5768
EC
3D
 1ozfA03 - 93.0
36148
Pyruvate dehydrogenase
Cytochrome
5698
EC
3D
 3ey9A03 - 92.8
35959
Pyruvate dehydrogenase [quinone]
5568
EC
3D
 3ey9A01 - 68.3
36616
2-oxoglutarate dehydrogenase, E1 component
5419
EC
3D
 3ai7A02 - 82.6
35573
D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
5364
EC
3D
 3ai7A01 - 89.5
36402
Oxalyl-CoA decarboxylase domain protein
5233
EC
3D
 2q27A01 - 93.7
36582
Pyruvate decarboxylase isozyme 1
4858
EC
3D
 1pvdA03 - 90.8
11434
2-oxoglutarate oxidoreductase, beta subunit
4841
EC
 - - 17.7
36574
Putative glyoxylate carboligase protein
4772
EC
3D
 2panA03 - 94.4
36244
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
4721
EC
3D
 2jlaA03 - 89.8
36158
Pyruvate-flavodoxin oxidoreductase
4406
EC
 - - 93.8
35863
Glyoxylate carboligase
3870
EC
 - - 44.9
36423
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
3033
EC
3D
 2x7jA03 - 93.4
35969
3D-
3,5/4
2132
EC
 - - 95.0
36350
Pyruvate decarboxylase isozyme 1
2027
EC
3D
 1pvdA01 - 94.2
36511
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1483
EC
 - - 94.6
36339
3D-
3,5/4
1470
EC
 - - 94.2
36359
Transketolase, N-terminal
Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase
1322
EC
3D
 3mosA01 - 79.9
36504
Putative 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1320
EC
3D
 5erxA03 - 91.5
36447
Acetolactate synthase large subunit
1165
EC
3D
 1ozfA01 - 88.5
36479
Sulfoacetaldehyde acetyltransferase
629
EC
 - - 90.2
36318
Pyruvate synthase, subunit beta
550
EC
 - - 94.4
36440
Putative pyruvate oxidase
455
EC
3D
 1powA01 - 56.9
36451
Sulfoacetaldehyde acetyltransferase
449
EC
 - - 79.2
12272
Pyruvate oxidase
417
EC
 - - 36.9
36021
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase family protein
410
EC
 - - 51.1
35940
Putative 2-hydroxyacyl-CoA lyase 1
371
EC
 - - 87.7
36197
Pyruvate synthase, subunit alpha
371
EC
 - - 95.3
36603
Acetolactate synthase large subunit
360
EC
3D
 4d5eA01 - 92.0
36587
2-oxoglutarate oxidoreductase beta subunit
350
EC
 - - 93.5
36454
Acetohydroxyacid synthase ilvX
327
EC
 - - 94.1
36564
Pyruvate synthase, subunit beta
276
EC
 - - 93.8
35788
Pyruvate decarboxylase isozyme 2
260
EC
 - - 63.7
12466
Probable Acetolactate synthase ilvG
Acetohydroxy-acid synthase ALS
254
EC
 - - 7.6
30388
Probable Acetolactate synthase ilvG
Acetohydroxy-acid synthase ALS
225
EC
 - - 0.0
16445
2-oxoglutarate ferredoxin oxidoreductase subunit alpha
220
EC
 - - 8.0
36212
Acetolactate synthase-like protein
210
EC
 - - 88.3
36251
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase
150
EC
 - - 78.6
12477
Aro10p
145
EC
 - - 14.9
36376
Acetolactate synthase-like protein
145 - - 78.1
12096
Aro10p
143
EC
 - - 0.6
28837
Putative OXALYL-CoA DECARBOXYLASE OXCA
134
EC
 - - 13.7
30987
Acetohydroxyacid synthase ilvX
130
EC
 - - 0.7
36207
Benzoylformate decarboxylase
108
EC
3D
 1bfdA03 - 42.7
36461
2-oxoglutarate oxidoreductase alpha subunit
88
EC
 - - 87.4
10940
2-oxoglutarate:acceptor oxidoreductase, OorA subunit
86
EC
 - - 18.4
35350
Transketolase, N-terminal subunit, putative
77
EC
 - - 50.7
36491
2-oxoglutarate synthase subunit KorB
75
EC
 - - 82.3
15971
Ferredoxin oxidoreductase, beta subunit
71
EC
 - - 1.9
26902
Putative Pyruvate oxidase/dehydrogenase
70
EC
 - - 21.2
25432
Putative acetolactate synthase large subunit
65
EC
 - - 15.3
36545
Sulfopyruvate decarboxylase subunit beta
65
EC
 - - 84.0
36549
Indolepyruvate oxidoreductase subunit IorA
61
EC
 - - 86.5
36352
Indolepyruvate oxidoreductase subunit IorA
56
EC
 - - 68.3
36390
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
52
EC
 - - 86.9
26884
Pyruvate dehydrogenase
Cytochrome
52
EC
 - - 0.7
29288
Pyruvate dehydrogenase
Cytochrome
50
EC
 - - 1.1
18850
Probable 2-ketoarginine decarboxylase AruI
45
EC
 - - 32.3
25978
Benzoylformate decarboxylase
41
EC
 - - 10.7
32340
Ferredoxin
Flavodoxin
37
EC
 - - 23.4
23454
Thiamine pyrophosphate protein TPP binding domain protein
36
EC
3D
 1zpdA01 - 1.6
19023
Transketolase, C-terminal subunit, putative
35
EC
 - - 22.6
15070
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
34
EC
 - - 10.9
25155
Conserved protein
33 - - 20.5
30553
Conserved protein
32 - - 9.6
36101
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
31
EC
 - - 63.0
34289
2-hydroxyacyl-CoA lyase 1 isoform 3
24 - - 43.6
31519
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
23
EC
 - - 4.6
25443
Indole-3-pyruvate decarboxylase
23
EC
3D
 2nxwA03 - 21.9
23952
Indole-3-pyruvate decarboxylase
23
EC
3D
 2nxwA01 - 34.6
10441
Probable 2-ketoarginine decarboxylase AruI
19
EC
 - - 1.4
36179
Sulfite reductase
NADPH
18
EC
 - - 62.9
10379
Pyruvate oxidase
16
EC
 - - 0.6
36575
Putative benzoylformate decarboxylase
16
EC
 - - 53.7
24395
Sulfoacetaldehyde acetyltransferase
16
EC
 - - 10.6
36538
Sulfopyruvate decarboxylase, alpha subunit
14
EC
 - - 85.4
7958
Uncharacterized protein
13 - - 58.5
15440
Phenylpyruvate decarboxylase
13 - - 8.0
36529
Transketolase-like protein 1 isoform a
12 - - 54.5
25149
Pyruvate decarboxylase, variant
9
EC
 - - 0.6
13886
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
8
EC
 - - 7.3
36189
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase
8
EC
 - - 38.4
35934
Phosphonopyruvate decarboxylase
8
EC
 - - 14.3
12797
Indolepyruvate oxidoreductase subunit IorA
6
EC
 - - 7.8
27449
Acetolactate synthase large subunit
6
EC
 - - 18.5
26141
Benzoylformate decarboxylase
6
EC
 - - 0.0
26083
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
6
EC
 - - 4.8
20797
Pyruvate dehydrogenase beta subunit
5
EC
 - - 0.0
13597
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
5
EC
 - - 1.7
36465
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
5
EC
 - - 51.2
28818
Protein PHYLLO, chloroplastic
4
EC
 - - 13.4
27116
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
4
EC
 - - 0.0
21561
Uncharacterized protein
4
EC
 - - 0.0
31513
Uncharacterized protein
4
EC
 - - 0.0
27690
Ketoisovalerate oxidoreductase subunit VorA
3
EC
 - - 17.0
35974
Probable pyruvate decarboxylase C186.09
3
EC
 - - 25.0
36181
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
3
EC
 - - 19.3
19444
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
2
EC
 - - 3.9
24455
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
2
EC
 - - 4.9
29685
Benzaldehyde lyase
2
EC
 - - 0.0
11986
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
2
EC
 - - 2.2
22927
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
2
EC
 - - 3.9
26358
Uncharacterized protein
2 - - 12.4
34676
Acetolactate synthase isozyme II large subunit
2
EC
 - - 4.1
35641
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
2
EC
 - - 13.5
34195
2-hydroxyacyl-CoA lyase 1
1 - - 0.0
10827
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
15387
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
14745
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
11263
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
19842
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
23451
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
31748
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
19450
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
30391
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
1
EC
 - - 0.0
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