CATH Domain 1pvdA01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.970	Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

Domain Context

CATH Clusters

Superfamily	3.40.50.970
Functional Family	Pyruvate decarboxylase isozyme 1

Enzyme Information

4.1.1.-	Carboxy-lyases. based on mapping to UniProt P06169
4.1.1.43	Phenylpyruvate decarboxylase. based on mapping to UniProt P06169 Phenylpyruvate = phenylacetaldehyde + CO(2). -!- Also acts on (indol-3-yl)pyruvate.
4.1.1.74	Indolepyruvate decarboxylase. based on mapping to UniProt P06169 3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2). -!- More specific than EC 4.1.1.1.
4.1.1.1	Pyruvate decarboxylase. based on mapping to UniProt P06169 A 2-oxo acid = an aldehyde + CO(2). -!- Also catalyzes acyloin formation.

UniProtKB Entries (1)

PDC1_YEAST

Saccharomyces cerevisiae S288C

Pyruvate decarboxylase isozyme 1

PDB Structure

PDB	1PVD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution. Arjunan, P., Umland, T., Dyda, F., Swaminathan, S., Furey, W., Sax, M., Farrenkopf, B., Gao, Y., Zhang, D., Jordan, F. J.Mol.Biol.