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CATH Superfamily 3.40.50.620

HUPs

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 87735: Glutamate--tRNA ligase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutamate--tRNA ligase. [EC: 6.1.1.17]
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
    		 354 A0A015PED3 A0A015PIB6 A0A015RVI0 A0A015SKE1 A0A015TVY8 A0A015V9N4 A0A015VJB9 A0A015W683 A0A015WZ94 A0A015X4T5
    (344 more...)
    Glutamate--tRNA(Gln) ligase. [EC: 6.1.1.24]
    ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx).
    • When this enzyme acts on tRNA(Glu), it catalyzes the same reaction as EC 6.1.1.17.
    • It has, however, diminished discrimination, so that it can also form glutamate-tRNA(Gln).
    • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
    • This accounts for the ability of this enzyme in, for example, Bacillus subtilis, to recognize both tRNA(1)(Gln) (UUG anticodon) and tRNA(Glu) (UUC anticodon) but not tRNA(2)(Gln) (CUG anticodon).
    • The ability of this enzyme to recognize both tRNA(Glu) and one of the tRNA(Gln) isoacceptors derives from their sharing a major identity element, a hypermodified derivative of U34 (5-methylaminomethyl-2- thiouridine).
    • The glutamyl-tRNA(Gln) is not used in protein synthesis until it is converted by EC 6.3.5.7 into glutaminyl-tRNA(Gln).
    		 4 A0A1J0LLC2 R7ZNK3 S2DC19 S7WP45