The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 624: Zinc finger protein ZFPM2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 D4A0R1 (/IPI) Q8CCH7 (/IPI) Q8WW38 (/IPI)
Transcription corepressor activity GO:0003714
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
2 Q8CCH7 (/IDA) Q8WW38 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
2 Q8CCH7 (/IPI) Q8WW38 (/IPI)
RNA polymerase II transcription coactivator activity GO:0001105
Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.
1 Q8WW38 (/NAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 Q8CCH7 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q8WW38 (/NAS)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
2 Q8CCH7 (/IMP) Q8WW38 (/IMP)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8CCH7 (/IDA)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 Q8CCH7 (/IDA)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 Q8CCH7 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q8CCH7 (/IMP)
Outflow tract septum morphogenesis GO:0003148
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
1 Q8WW38 (/IMP)
Outflow tract septum morphogenesis GO:0003148
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
1 Q8CCH7 (/ISO)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
1 Q8CCH7 (/TAS)
Atrioventricular valve morphogenesis GO:0003181
The process in which the structure of the atrioventricular valve is generated and organized.
1 Q8CCH7 (/TAS)
Mitral valve formation GO:0003192
The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
1 Q8CCH7 (/TAS)
Tricuspid valve formation GO:0003195
The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
1 Q8CCH7 (/TAS)
Right ventricular cardiac muscle tissue morphogenesis GO:0003221
The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.
1 Q8WW38 (/IMP)
Right ventricular cardiac muscle tissue morphogenesis GO:0003221
The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.
1 Q8CCH7 (/ISO)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q8CCH7 (/IDA)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q8CCH7 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 Q8WW38 (/TAS)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
1 Q8CCH7 (/IMP)
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
1 Q8CCH7 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8WW38 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8CCH7 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8CCH7 (/TAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8CCH7 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8CCH7 (/TAS)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8WW38 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8CCH7 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8CCH7 (/ISO)
Embryonic organ development GO:0048568
Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q8CCH7 (/IMP)
Embryonic organ development GO:0048568
Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q8CCH7 (/ISO)
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
1 Q8CCH7 (/IMP)
Cardiac muscle tissue morphogenesis GO:0055008
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
1 Q8CCH7 (/TAS)
Positive regulation of cardiac muscle cell proliferation GO:0060045
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
1 Q8CCH7 (/IGI)
Ventricular septum morphogenesis GO:0060412
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
1 Q8WW38 (/IMP)
Ventricular septum morphogenesis GO:0060412
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
1 Q8CCH7 (/ISO)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 Q8CCH7 (/IMP)
Vasculogenesis involved in coronary vascular morphogenesis GO:0060979
The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.
1 Q8CCH7 (/TAS)
Positive regulation of male gonad development GO:2000020
Any process that activates or increases the frequency, rate or extent of male gonad development.
1 Q8CCH7 (/IMP)
Negative regulation of female gonad development GO:2000195
Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.
1 Q8CCH7 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 D4A0R1 (/IDA) Q8CCH7 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 E7ET52 (/IDA) Q8WW38 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8CCH7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8WW38 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8CCH7 (/IDA)