CATH Domain 3ky7A01
|3.40.1280.10||SPOUT methyltransferase, trefoil knot domain|
|Functional Family||tRNA (guanine-N(1)-)-methyltransferase|
based on mapping to UniProt Q6GHJ5
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 184.108.40.206.
UniProtKB Entries (1)
Staphylococcus aureus subsp. aureus MRSA252
2.35 Angstrom resolution crystal structure of a putative tRNA (guanine-7-)-methyltransferase (trmD) from Staphylococcus aureus subsp. aureus MRSA252
To be Published