CATH Domain 1uamA01
|3.40.1280.10||SPOUT methyltransferase, trefoil knot domain|
|Functional Family||tRNA (guanine-N(1)-)-methyltransferase|
based on mapping to UniProt P43912
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 220.127.116.11.
UniProtKB Entries (1)
Haemophilus influenzae Rd KW20
Crystal structure of tRNA(m(1)G37)methyltransferase: insights into tRNA recognition