PDB 5nvx

PDB Information

PDB5NVX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.
HeaderLigase
Released2017-05-04
Resolution2.200
CATH Insert Date14 Nov, 2017

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5nvxA00 10 Dec, 2017 3.10.20.90 Assigned
5nvxB00 10 Dec, 2017 3.30.710.10 Assigned
5nvxC01 10 Dec, 2017 2.60.40.780 Assigned
5nvxC02 10 Dec, 2017 1.10.750.10 Assigned
5nvxD00 10 Dec, 2017 3.10.20.90 Assigned
5nvxE00 10 Dec, 2017 3.30.710.10 Assigned
5nvxF01 10 Dec, 2017 2.60.40.780 Assigned
5nvxF02 10 Dec, 2017 1.10.750.10 Assigned
5nvxG00 10 Dec, 2017 3.10.20.90 Assigned
5nvxH00 10 Dec, 2017 3.30.710.10 Assigned
5nvxI01 10 Dec, 2017 2.60.40.780 Assigned
5nvxI02 10 Dec, 2017 1.10.750.10 Assigned
5nvxJ00 10 Dec, 2017 3.10.20.90 Assigned
5nvxK00 10 Dec, 2017 3.30.710.10 Assigned
5nvxL01 10 Dec, 2017 2.60.40.780 Assigned
5nvxL02 10 Dec, 2017 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B