PDB 5nvx
PDB Information
| PDB | 5NVX |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli |
| Gene Source | Homo sapiens |
| Primary Citation | Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
J. Med. Chem.
|
| Header | Ligase |
| Released | 2017-05-04 |
| Resolution | 2.200 |
| CATH Insert Date | 14 Nov, 2017 |
PDB Images (29)
5nvx
PDB 5nvx
5nvxA
PDB Chain 5nvxA
5nvxB
PDB Chain 5nvxB
5nvxC
PDB Chain 5nvxC
5nvxD
PDB Chain 5nvxD
5nvxE
PDB Chain 5nvxE
5nvxF
PDB Chain 5nvxF
5nvxG
PDB Chain 5nvxG
5nvxH
PDB Chain 5nvxH
5nvxI
PDB Chain 5nvxI
5nvxJ
PDB Chain 5nvxJ
5nvxK
PDB Chain 5nvxK
5nvxL
PDB Chain 5nvxL
5nvxA00
CATH Domain 5nvxA00
5nvxB00
CATH Domain 5nvxB00
5nvxC01
CATH Domain 5nvxC01
5nvxC02
CATH Domain 5nvxC02
5nvxD00
CATH Domain 5nvxD00
5nvxE00
CATH Domain 5nvxE00
5nvxF01
CATH Domain 5nvxF01
5nvxF02
CATH Domain 5nvxF02
5nvxG00
CATH Domain 5nvxG00
5nvxH00
CATH Domain 5nvxH00
5nvxI01
CATH Domain 5nvxI01
5nvxI02
CATH Domain 5nvxI02
5nvxJ00
CATH Domain 5nvxJ00
5nvxK00
CATH Domain 5nvxK00
5nvxL01
CATH Domain 5nvxL01
5nvxL02
CATH Domain 5nvxL02
PDB Prints
PDB Chains (12)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 14 Nov, 2017 | Chopped |
| B | 14 Nov, 2017 | Chopped |
| C | 14 Nov, 2017 | Chopped |
| D | 14 Nov, 2017 | Chopped |
| E | 14 Nov, 2017 | Chopped |
| F | 14 Nov, 2017 | Chopped |
| G | 14 Nov, 2017 | Chopped |
| H | 14 Nov, 2017 | Chopped |
| I | 14 Nov, 2017 | Chopped |
| J | 14 Nov, 2017 | Chopped |
| K | 14 Nov, 2017 | Chopped |
| L | 14 Nov, 2017 | Chopped |
CATH Domains (16)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 5nvxA00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nvxB00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nvxC01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nvxC02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nvxD00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nvxE00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nvxF01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nvxF02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nvxG00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nvxH00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nvxI01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nvxI02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nvxJ00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nvxK00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nvxL01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nvxL02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
UniProtKB Entries (12)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
