PDB 5kq5

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Overview

PDB Information

PDB	5KQ5
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Rattus norvegicus
Primary Citation	Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. Cameron, K.O., Kung, D.W., Kalgutkar, A.S., Kurumbail, R.G., Miller, R., Salatto, C.T., Ward, J., Withka, J.M., Bhattacharya, S.K., Boehm, M., Borzilleri, K.A., Brown, J.A., Calabrese, M., Caspers, N.L., Cokorinos, E., Conn, E.L., Dowling, M.S., Edmonds, D.J., Eng, H., Fernando, D.P., Frisbie, R., Hepworth, D., Landro, J., Mao, Y., Rajamohan, F., Reyes, A.R., Rose, C.R., Ryder, T., Shavnya, A., Smith, A.C., Tu, M., Wolford, A.C., Xiao, J. J.Med.Chem.
Header	Transferase
Released	2016-07-05
Resolution	3.410
CATH Insert Date	04 Sep, 2016

PDB Images (7)

Image of CATH 5kq5

5kq5

PDB 5kq5

Image of CATH 5kq5A

5kq5A

PDB Chain 5kq5A

Image of CATH 5kq5B

5kq5B

PDB Chain 5kq5B

Image of CATH 5kq5C

5kq5C

PDB Chain 5kq5C

Image of CATH 5kq5B01

5kq5B01

CATH Domain 5kq5B01

Image of CATH 5kq5B02

5kq5B02

CATH Domain 5kq5B02

Image of CATH 5kq5C00

5kq5C00

CATH Domain 5kq5C00

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	05 Sep, 2016	Holding pen
B	05 Sep, 2016	Chopped
C	05 Sep, 2016	Chopped

CATH Domains (3)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5kq5B01	25 Jun, 2018		Holding pen
5kq5B02	25 Jun, 2018	6.20.250.60	Assigned
5kq5C00	14 Nov, 2017		Holding pen

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P80386	AAKB1_RAT	Rattus norvegicus	5'-AMP-activated protein kinase subunit beta-1
P54645	AAPK1_RAT	Rattus norvegicus	5'-AMP-activated protein kinase catalytic subunit alpha-1
P80385	AAKG1_RAT	Rattus norvegicus	5'-AMP-activated protein kinase subunit gamma-1