CATH Domain 5kq5B02

CATH Classification

Level	CATH Code	Description
	6	Special
	6.20	Other non-globular
	6.20.250	Double Stranded RNA Binding Domain
	6.20.250.60

Domain Context

CATH Clusters

Superfamily	6.20.250.60
Functional Family

Enzyme Information

UniProtKB Entries (1)

AAKG1_RAT

Rattus norvegicus

5'-AMP-activated protein kinase subunit gamma-1

PDB Structure

PDB	5KQ5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. Cameron, K.O., Kung, D.W., Kalgutkar, A.S., Kurumbail, R.G., Miller, R., Salatto, C.T., Ward, J., Withka, J.M., Bhattacharya, S.K., Boehm, M., Borzilleri, K.A., Brown, J.A., Calabrese, M., Caspers, N.L., Cokorinos, E., Conn, E.L., Dowling, M.S., Edmonds, D.J., Eng, H., Fernando, D.P., Frisbie, R., Hepworth, D., Landro, J., Mao, Y., Rajamohan, F., Reyes, A.R., Rose, C.R., Ryder, T., Shavnya, A., Smith, A.C., Tu, M., Wolford, A.C., Xiao, J. J.Med.Chem.