Beta Hairpin

The simplest type of up-down antiparallel beta-sheet topology whereby two adjacent antiparallel strands are joined by a loop. This motif occurs very frequently in nature and can be observed in many different beta-sheet structures.

The example given below is the epidermal growth factor-like domain of heregulin-alpha (CATH domain ID 1hreA00).


beta-Sheet topology and the relatedness of proteins.
Richardson JS
Nature268p495-500(1977 Aug 11)