The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cytosolic phospholipase A2 catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Patatin-like phospholipase domain-containing prote...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
5 Q2KI18 (/ISS) Q2KI18 (/ISS) Q91WW7 (/ISS) Q96AD5 (/ISS) Q9VXY8 (/ISS)
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
3 E1JI03 (/IDA) Q91WW7 (/IDA) Q9NST1 (/IDA)
1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841
Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
2 Q32LZ8 (/ISO) Q91WW7 (/ISO)
Lysophosphatidic acid binding GO:0035727
Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Long-chain fatty acyl-CoA binding GO:0036042
Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Lysophosphatidic acid acyltransferase activity GO:0042171
Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841
Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
1 Q91WW7 (/ISO)
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
1 Q9NST1 (/IDA)
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
1 Q91WW7 (/ISO)
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
1 Q91WW7 (/ISS)
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
1 Q7Z6Z6 (/EXP)
Lysophosphatidic acid binding GO:0035727
Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors.
1 Q91WW7 (/ISO)
Long-chain fatty acyl-CoA binding GO:0036042
Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
1 Q91WW7 (/ISO)
Lysophosphatidic acid acyltransferase activity GO:0042171
Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid.
1 Q91WW7 (/ISO)
Mono-olein transacylation activity GO:0051264
Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol.
1 Q9NST1 (/IDA)
Mono-olein transacylation activity GO:0051264
Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol.
1 Q91WW7 (/ISO)
Diolein transacylation activity GO:0051265
Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein.
1 Q9NST1 (/IDA)
Diolein transacylation activity GO:0051265
Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein.
1 Q91WW7 (/ISO)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
2 A0A0R4IUV2 (/IMP) Q6DHN9 (/IMP)
Triglyceride mobilization GO:0006642
The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.
2 E1JI03 (/IMP) Q9VUH7 (/IMP)
Glycerophospholipid metabolic process GO:0006650
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Phosphatidic acid biosynthetic process GO:0006654
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Positive regulation of lipid storage GO:0010884
Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
2 E1JI03 (/IDA) Q9VUH7 (/IDA)
Negative regulation of sequestering of triglyceride GO:0010891
Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
2 Q2KI18 (/ISS) Q2KI18 (/ISS)
Positive regulation of triglyceride catabolic process GO:0010898
Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
2 Q2KI18 (/ISS) Q2KI18 (/ISS)
Lipid catabolic process GO:0016042
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
2 E1JI03 (/IMP) Q9VUH7 (/IMP)
Triglyceride biosynthetic process GO:0019432
The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Triglyceride catabolic process GO:0019433
The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Triglyceride catabolic process GO:0019433
The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.
2 Q91WW7 (/ISS) Q9VXY8 (/ISS)
Acylglycerol acyl-chain remodeling GO:0036155
Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains.
2 Q96AD5 (/TAS) Q9NST1 (/TAS)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
2 E1JI03 (/IMP) Q9VUH7 (/IMP)
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q91WW7 (/ISO)
Response to dietary excess GO:0002021
The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
1 Q91WW7 (/IMP)
Glycerophospholipid metabolic process GO:0006650
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
1 Q91WW7 (/ISO)
Phosphatidic acid biosynthetic process GO:0006654
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q91WW7 (/ISO)
Negative regulation of sequestering of triglyceride GO:0010891
Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
1 Q96AD5 (/IDA)
Negative regulation of sequestering of triglyceride GO:0010891
Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
1 E1JI03 (/IMP)
Positive regulation of triglyceride catabolic process GO:0010898
Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
1 Q96AD5 (/IDA)
Triglyceride biosynthetic process GO:0019432
The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
1 Q91WW7 (/ISO)
Triglyceride biosynthetic process GO:0019432
The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
1 Q91WW7 (/ISS)
Triglyceride catabolic process GO:0019433
The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.
1 E1JI03 (/IMP)
Triglyceride catabolic process GO:0019433
The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.
1 Q91WW7 (/ISO)
Triglyceride catabolic process GO:0019433
The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.
1 Q7Z6Z6 (/TAS)
Lipid droplet organization GO:0034389
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
1 Q9NST1 (/IMP)
Lipid droplet organization GO:0034389
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
1 Q91WW7 (/ISO)
Triglyceride acyl-chain remodeling GO:0036153
Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains.
1 Q9NST1 (/IDA)
Triglyceride acyl-chain remodeling GO:0036153
Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains.
1 Q91WW7 (/ISO)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
1 Q96AD5 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
1 Q96AD5 (/TAS)
Triglyceride homeostasis GO:0070328
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
1 E1JI03 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
5 E1JI03 (/IDA) Q91WW7 (/IDA) Q96AD5 (/IDA) Q9NST1 (/IDA) Q9VUH7 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q96AD5 (/TAS) Q9NST1 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 E1JI03 (/HDA) Q9VUH7 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q91WW7 (/IDA) Q9NST1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q96AD5 (/IDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
1 Q96AD5 (/TAS)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 Q91WW7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q7Z6Z6 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q91WW7 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9NST1 (/ISS)
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