The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Alpha-crystallin A chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P02470 (/IPI) P02489 (/IPI) P02489 (/IPI) P02489 (/IPI) P02489 (/IPI) P02489 (/IPI) P24622 (/IPI) P24622 (/IPI) P24623 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 P02489 (/IPI) P02489 (/IPI) P02489 (/IPI) P02489 (/IPI) P02489 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
5 P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P02489 (/IMP)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
5 P02489 (/IPI) P02489 (/IPI) P02489 (/IPI) P02489 (/IPI) P02489 (/IPI)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
5 P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS)
Structural constituent of eye lens GO:0005212
The action of a molecule that contributes to the structural integrity of the lens of an eye.
3 P24622 (/TAS) P24622 (/TAS) P24623 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P24622 (/ISO) P24622 (/ISO)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
2 P02470 (/IDA) Q8UUZ6 (/IDA)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
2 P24622 (/ISO) P24622 (/ISO)
Structural constituent of eye lens GO:0005212
The action of a molecule that contributes to the structural integrity of the lens of an eye.
1 Q8UUZ6 (/NAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P24623 (/IDA)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
7 P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P24622 (/IMP) P24622 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
6 P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P24623 (/IDA)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
5 P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P02489 (/IMP)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
5 P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS)
Negative regulation of intracellular transport GO:0032387
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
5 P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA)
Negative regulation of intracellular transport GO:0032387
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
5 P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
5 P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
5 P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
5 P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P02489 (/IMP) P02489 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
5 P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
3 P24622 (/IMP) P24622 (/IMP) Q8UUZ6 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P24622 (/IMP) P24622 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
2 P24622 (/IMP) P24622 (/IMP)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
2 P24622 (/IGI) P24622 (/IGI)
Lens morphogenesis in camera-type eye GO:0002089
The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
2 P24622 (/IMP) P24622 (/IMP)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2 P24622 (/ISO) P24622 (/ISO)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2 P24622 (/IMP) P24622 (/IMP)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 P24622 (/IMP) P24622 (/IMP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
2 P24622 (/IMP) P24622 (/IMP)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
2 P24622 (/IMP) P24622 (/IMP)
Tubulin complex assembly GO:0007021
The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer.
2 P24622 (/IMP) P24622 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P24622 (/IMP) P24622 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 P24622 (/IMP) P24622 (/IMP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 P24622 (/IMP) P24622 (/IMP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 P24622 (/ISO) P24622 (/ISO)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
2 P24622 (/IGI) P24622 (/IGI)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
2 P24622 (/IGI) P24622 (/IGI)
Embryonic camera-type eye morphogenesis GO:0048596
The process in which the anatomical structures of the eye are generated and organized during embryonic development.
2 P24622 (/IMP) P24622 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 P24622 (/ISO) P24622 (/ISO)
Apoptotic process involved in morphogenesis GO:0060561
Any apoptotic process that contributes to the shaping of an anatomical structure.
2 P24622 (/IGI) P24622 (/IGI)
Response to UV-A GO:0070141
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm.
2 P24622 (/IMP) P24622 (/IMP)
Lens fiber cell morphogenesis GO:0070309
The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
2 P24622 (/IMP) P24622 (/IMP)
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
1 Q8UUZ6 (/IDA)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
1 P24623 (/IEP)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 P24623 (/IDA)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 Q8UUZ6 (/NAS)
Multicellular organism aging GO:0010259
An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
1 P24623 (/IEP)
Response to lead ion GO:0010288
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 P24623 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P24623 (/IEP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P24623 (/IDA)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P24623 (/IEP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
97 P02470 (/ISS) P02472 (/ISS) P02474 (/ISS) P02474 (/ISS) P02475 (/ISS) P02476 (/ISS) P02477 (/ISS) P02477 (/ISS) P02478 (/ISS) P02479 (/ISS)
(87 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
93 P02472 (/ISS) P02474 (/ISS) P02474 (/ISS) P02475 (/ISS) P02476 (/ISS) P02477 (/ISS) P02477 (/ISS) P02478 (/ISS) P02479 (/ISS) P02480 (/ISS)
(83 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
13 A0A096LPJ9 (/IDA) A0A140G945 (/IDA) A0A140G945 (/IDA) A0A140G945 (/IDA) A0A140G945 (/IDA) A0A140G945 (/IDA) E7EWH7 (/IDA) E7EWH7 (/IDA) P02489 (/IDA) P02489 (/IDA)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 A0A096LPJ9 (/IDA) A0A140G945 (/IDA) A0A140G945 (/IDA) A0A140G945 (/IDA) A0A140G945 (/IDA) A0A140G945 (/IDA) E7EWH7 (/IDA) E7EWH7 (/IDA) P02489 (/IDA) P02489 (/IDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P02470 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P24622 (/IDA) P24622 (/IDA) P24623 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA) P02489 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS) P02504 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P24622 (/ISO) P24622 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P24622 (/ISO) P24622 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P24622 (/ISO) P24622 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P24622 (/ISO) P24622 (/ISO)
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