The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 1270: MPL proto-oncogene, thrombopoietin receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P40238 (/IPI) |
Thrombopoietin receptor activity GO:0038164
Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P40238 (/IMP) |
Thrombopoietin receptor activity GO:0038164
Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | Q08351 (/ISO) |
Thrombopoietin receptor activity GO:0038164
Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | Q08351 (/ISS) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Neutrophil homeostasis GO:0001780
The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
5 | A0A1W2Q670 (/IMP) A0A1W2Q6A7 (/IMP) A0A1W2Q6G3 (/IMP) A0A1W2Q6N1 (/IMP) D4A2R0 (/IMP) |
Monocyte homeostasis GO:0035702
The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
5 | A0A1W2Q670 (/IMP) A0A1W2Q6A7 (/IMP) A0A1W2Q6G3 (/IMP) A0A1W2Q6N1 (/IMP) D4A2R0 (/IMP) |
Positive regulation of lymphocyte proliferation GO:0050671
Any process that activates or increases the rate or extent of lymphocyte proliferation.
|
5 | A0A1W2Q670 (/IMP) A0A1W2Q6A7 (/IMP) A0A1W2Q6G3 (/IMP) A0A1W2Q6N1 (/IMP) D4A2R0 (/IMP) |
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
|
5 | A0A1W2Q670 (/IEP) A0A1W2Q6A7 (/IEP) A0A1W2Q6G3 (/IEP) A0A1W2Q6N1 (/IEP) D4A2R0 (/IEP) |
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
5 | A0A1W2Q670 (/IEP) A0A1W2Q6A7 (/IEP) A0A1W2Q6G3 (/IEP) A0A1W2Q6N1 (/IEP) D4A2R0 (/IEP) |
Positive regulation of platelet formation GO:1905221
Any process that activates or increases the frequency, rate or extent of platelet formation.
|
5 | A0A1W2Q670 (/IMP) A0A1W2Q6A7 (/IMP) A0A1W2Q6G3 (/IMP) A0A1W2Q6N1 (/IMP) D4A2R0 (/IMP) |
Eosinophil homeostasis GO:1990959
The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
5 | A0A1W2Q670 (/IMP) A0A1W2Q6A7 (/IMP) A0A1W2Q6G3 (/IMP) A0A1W2Q6N1 (/IMP) D4A2R0 (/IMP) |
Basophil homeostasis GO:1990960
The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
5 | A0A1W2Q670 (/IMP) A0A1W2Q6A7 (/IMP) A0A1W2Q6G3 (/IMP) A0A1W2Q6N1 (/IMP) D4A2R0 (/IMP) |
Neutrophil homeostasis GO:0001780
The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
1 | Q08351 (/ISO) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q08351 (/IMP) |
Platelet formation GO:0030220
The process in which platelets bud from long processes extended by megakaryocytes.
|
1 | Q08351 (/IGI) |
Regulation of chemokine production GO:0032642
Any process that modulates the frequency, rate, or extent of chemokine production.
|
1 | Q08351 (/IMP) |
Monocyte homeostasis GO:0035702
The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
1 | Q08351 (/ISO) |
Thrombopoietin-mediated signaling pathway GO:0038163
A series of molecular signals initiated by the binding of a thrombopoietin to the thrombopoietin receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q08351 (/IDA) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q08351 (/IMP) |
Homeostasis of number of cells GO:0048872
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
|
1 | Q08351 (/IMP) |
Positive regulation of lymphocyte proliferation GO:0050671
Any process that activates or increases the rate or extent of lymphocyte proliferation.
|
1 | Q08351 (/ISO) |
Definitive hemopoiesis GO:0060216
A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
|
1 | Q08351 (/IMP) |
Regulation of stem cell proliferation GO:0072091
Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
1 | Q08351 (/IMP) |
Positive regulation of platelet formation GO:1905221
Any process that activates or increases the frequency, rate or extent of platelet formation.
|
1 | Q08351 (/ISO) |
Eosinophil homeostasis GO:1990959
The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
1 | Q08351 (/ISO) |
Basophil homeostasis GO:1990960
The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
1 | Q08351 (/ISO) |
Regulation of stem cell division GO:2000035
Any process that modulates the frequency, rate or extent of stem cell division.
|
1 | Q08351 (/IMP) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
6 | A0A1W2Q670 (/IDA) A0A1W2Q6A7 (/IDA) A0A1W2Q6G3 (/IDA) A0A1W2Q6N1 (/IDA) D4A2R0 (/IDA) P40238 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | A0A1W2Q670 (/IDA) A0A1W2Q6A7 (/IDA) A0A1W2Q6G3 (/IDA) A0A1W2Q6N1 (/IDA) D4A2R0 (/IDA) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
5 | A0A1W2Q670 (/IDA) A0A1W2Q6A7 (/IDA) A0A1W2Q6G3 (/IDA) A0A1W2Q6N1 (/IDA) D4A2R0 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
5 | A0A1W2Q670 (/IDA) A0A1W2Q6A7 (/IDA) A0A1W2Q6G3 (/IDA) A0A1W2Q6N1 (/IDA) D4A2R0 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | P40238 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q08351 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q08351 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q08351 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P40238 (/TAS) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q08351 (/ISO) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q08351 (/ISS) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q08351 (/ISO) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q08351 (/ISO) |