The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Amino acid/polyamine transporter I
".
FunFam 5: Solute carrier family 12 member 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P55011 (/IPI) P55011 (/IPI) P55012 (/IPI) P55014 (/IPI) |
|
Sodium:potassium:chloride symporter activity GO:0008511
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).
|
3 | P55011 (/TAS) P55011 (/TAS) Q13621 (/TAS) |
|
Sodium:potassium:chloride symporter activity GO:0008511
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).
|
2 | A9NJG3 (/IDA) P55016 (/IDA) |
|
Sodium:potassium:chloride symporter activity GO:0008511
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).
|
2 | E9PTX9 (/IMP) Q9QX10 (/IMP) |
|
Sodium:potassium:chloride symporter activity GO:0008511
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).
|
2 | P55012 (/ISO) P55014 (/ISO) |
|
Ammonium transmembrane transporter activity GO:0008519
Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.
|
2 | P55011 (/IDA) P55011 (/IDA) |
|
Cation:chloride symporter activity GO:0015377
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).
|
2 | E9PTX9 (/TAS) Q9QX10 (/TAS) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | P55011 (/IPI) P55011 (/IPI) |
|
Ammonium transmembrane transporter activity GO:0008519
Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.
|
1 | P55012 (/ISO) |
|
Symporter activity GO:0015293
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
|
1 | A9NJG3 (/IDA) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | P55012 (/ISO) |
There are 44 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
|
4 | A0A0G2KGS0 (/IMP) A0A0G2KTI4 (/IMP) C7EA90 (/IMP) Q6IQW8 (/IMP) |
|
Ear development GO:0043583
The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
|
4 | A0A0G2KGS0 (/IMP) A0A0G2KTI4 (/IMP) C7EA90 (/IMP) Q6IQW8 (/IMP) |
|
Swim bladder inflation GO:0048798
The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ.
|
4 | A0A0G2KGS0 (/IMP) A0A0G2KTI4 (/IMP) C7EA90 (/IMP) Q6IQW8 (/IMP) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | P55011 (/TAS) P55011 (/TAS) Q13621 (/TAS) |
|
T cell chemotaxis GO:0010818
The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
|
3 | P55011 (/IMP) P55011 (/IMP) P55012 (/IMP) |
|
Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
|
3 | P55011 (/IMP) P55011 (/IMP) P55012 (/IMP) |
|
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | E9PTX9 (/IMP) Q9QX10 (/IMP) |
|
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P55012 (/ISO) P55014 (/ISO) |
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | E9PTX9 (/IMP) Q9QX10 (/IMP) |
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P55012 (/ISO) P55014 (/ISO) |
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | E9PTX9 (/IMP) Q9QX10 (/IMP) |
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P55012 (/ISO) P55014 (/ISO) |
|
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
2 | E9PTX9 (/IMP) Q9QX10 (/IMP) |
|
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
2 | E9PTX9 (/IEP) Q9QX10 (/IEP) |
|
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
2 | E9PTX9 (/IEP) Q9QX10 (/IEP) |
|
Ammonium transport GO:0015696
The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.
|
2 | P55011 (/IDA) P55011 (/IDA) |
|
Transepithelial chloride transport GO:0030321
The directed movement of chloride ions from one side of an epithelium to the other.
|
2 | P55011 (/IDA) P55011 (/IDA) |
|
Positive regulation of cell volume GO:0045795
Any process that increases cell volume.
|
2 | E9PTX9 (/IMP) Q9QX10 (/IMP) |
|
Transepithelial ammonium transport GO:0070634
The directed movement of ammonium ions from one side of an epithelium to the other.
|
2 | P55011 (/IDA) P55011 (/IDA) |
|
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
1 | P55014 (/IMP) |
|
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P55016 (/IDA) |
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P55016 (/IDA) |
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P55016 (/IDA) |
|
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
1 | P55012 (/ISO) |
|
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
|
1 | P55014 (/IMP) |
|
T cell chemotaxis GO:0010818
The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
|
1 | P55012 (/ISO) |
|
Ammonium transport GO:0015696
The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.
|
1 | P55012 (/ISO) |
|
Diterpenoid metabolic process GO:0016101
The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.
|
1 | P55016 (/IEP) |
|
Transepithelial chloride transport GO:0030321
The directed movement of chloride ions from one side of an epithelium to the other.
|
1 | P55012 (/ISO) |
|
Protein insertion into membrane from inner side GO:0032978
The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side.
|
1 | P55016 (/IDA) |
|
Protein insertion into membrane from inner side GO:0032978
The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side.
|
1 | P55014 (/ISO) |
|
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
1 | P55016 (/IDA) |
|
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
1 | P55014 (/ISO) |
|
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
1 | Q13621 (/ISS) |
|
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
|
1 | P55012 (/IMP) |
|
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
1 | A9NJG3 (/IDA) |
|
Positive regulation of cell volume GO:0045795
Any process that increases cell volume.
|
1 | P55012 (/ISO) |
|
Chemical homeostasis GO:0048878
Any biological process involved in the maintenance of an internal steady state of a chemical.
|
1 | P55014 (/IMP) |
|
Detection of mechanical stimulus involved in sensory perception of sound GO:0050910
The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
|
1 | P55012 (/IMP) |
|
Branching involved in mammary gland duct morphogenesis GO:0060444
The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
|
1 | P55012 (/IMP) |
|
Mammary duct terminal end bud growth GO:0060763
The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty.
|
1 | P55012 (/IMP) |
|
Renal sodium ion absorption GO:0070294
A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
|
1 | P55016 (/IC) |
|
Transepithelial ammonium transport GO:0070634
The directed movement of ammonium ions from one side of an epithelium to the other.
|
1 | P55012 (/ISO) |
|
Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
|
1 | P55012 (/ISO) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
6 | A0A0G2KGS0 (/IDA) A0A0G2KTI4 (/IDA) A9NJG3 (/IDA) C7EA90 (/IDA) P55012 (/IDA) Q6IQW8 (/IDA) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
4 | A0A0R4IYN4 (/IDA) P55012 (/IDA) P55014 (/IDA) P55016 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | E9PTX9 (/IDA) P55016 (/IDA) Q9QX10 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P55011 (/TAS) P55011 (/TAS) Q13621 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | P55011 (/TAS) P55011 (/TAS) Q13621 (/TAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
3 | P55011 (/HDA) P55011 (/HDA) Q13621 (/HDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P55012 (/ISO) P55014 (/ISO) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P55011 (/TAS) P55011 (/TAS) |
|
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
|
2 | P55011 (/HDA) P55011 (/HDA) |
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
1 | A9NJG3 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | A9NJG3 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P55016 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P55014 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | A9NJG3 (/IDA) |
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | O18978 (/ISS) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | P55014 (/ISO) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | O18978 (/ISS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q13621 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P55014 (/ISO) |
