CATH Domain 6n7bA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P23458

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P23458

JAK1_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK1

PDB Structure

PDB	6N7B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Zak, M., Hanan, E.J., Lupardus, P., Brown, D.G., Robinson, C., Siu, M., Lyssikatos, J.P., Romero, F.A., Zhao, G., Kellar, T., Mendonca, R., Ray, N.C., Goodacre, S.C., Crackett, P.H., McLean, N., Hurley, C.A., Yuen, P.W., Cheng, Y.X., Liu, X., Liimatta, M., Kohli, P.B., Nonomiya, J., Salmon, G., Buckley, G., Lloyd, J., Gibbons, P., Ghilardi, N., Kenny, J.R., Johnson, A. Bioorg.Med.Chem.Lett.